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L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1

By Lin Cheng, Qiulian Wu, Zhi Huang, Olga A Guryanova, Qian Huang, Weinian Shou, Jeremy N Rich and Shideng Bao


Radioresistance of glioblastomas has been correlated with increased DNA repair capacities of glioblastoma stem cells. This is now linked to a surface marker of such stem cells, whose radiation-induced intramembrane proteolysis induces expression of a key DNA repair gene

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Publisher: Nature Publishing Group
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Provided by: PubMed Central
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