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Macrocyclic β-Sheet Peptides That Inhibit the Aggregation of a Tau-Protein-Derived Hexapeptide

By Jing Zheng, Cong Liu, Michael R. Sawaya, Balraju Vadla, Shafiullah Khan, R. Jeremy Woods, David Eisenberg, Warren J. Goux and James S. Nowick
Publisher: American Chemical Society
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Provided by: PubMed Central

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  11. Initially we tried using Teflon mixing balls in the wells, but we found that the data were more reproducible and less noisy without mixing balls. Teflon mixing balls are commonly used in ThT fluorescence assays of Aβ aggregation.
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  13. The macrocycles are named with the one-letter codes for residues at the R1-R7 positions.
  14. (2000). The molecular template is called “Hao” because it comprises hydrazine, 5-amino-2-methoxybenzoic acid, and oxalic acid groups.
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