Thyroid Transcription Factor‐1 Regulates Feeding Behavior via Melanocortin Pathway in the Hypothalamus
By Jae Geun Kim, Byong Seo Park, Chang Ho Yun, Hyun Jun Kim, Sang Soo Kang, Angela Valentina D’Elia, Giuseppe Damante, Ki-Up Lee, Jeong Woo Park, Eun Sook Kim, Il Seong Namgoong, Young Il Kim and Byung Ju Lee
A molecular code dictates sequence-speciﬁc DNA recognition by homeodomains.
(1989). A thyroid-speciﬁc nuclear protein essential for tissue-speciﬁc expression of the thyroglobulin promoter.
Anatomy and regulation of the central melanocortin system.
(1997). Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein.
(2011). Central alpha-msh infusion in rats: Disparate anorexic vs. metabolic changes with aging.
(1999). Co-operation between the PAI and RED subdomains of Pax-8 in the interaction with the thyroglobulin promoter.
Deletion of the Ttf1 gene in differentiated neurons disrupts female reproduction without impairing basal ganglia function.
Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deﬁciency.
Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat.
Feeding and behavioural effects of central administration of the melanocortin 3/4-R antagonist SHU9119 in obese and lean Siberian hamsters.
Hypothalamic, metabolic, and behavioral responses to pharmacological inhibition of CNS melanocortin signaling in rats.
Immunohistochemical analyses of thyroid-speciﬁc enhancer-binding protein in the fetal and adult rat hypothalami and pituitary glands.
(2005). Leptin-like effects of MTII are augmented in MSG-obese rats. Regul Pept
Melanocortin receptors in leptin effects.
Neuroendocrine control of food intake.
(1999). Obesity in the mouse model of pro-opiomelanocortin deﬁciency responds to peripheral melanocortin.
Regulation of pituitary adenylate cyclaseactivating polypeptide gene transcription by TTF-1, a homeodomaincontaining transcription factor.
(2009). Role of central melanocortin pathways in energy homeostasis. Trends Endocrinol Metab
Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis.
(1997). Role of melanocortinergic neurons in feeding and the agouti obesity syndrome.
(1997). Targeted disruption of the melanocortin-4 receptor results in obesity in mice.
The gene structure and minimal promoter of the human agouti related protein.
The leptin-dependent and -independent melanocortin signaling system: regulation of feeding and energy expenditure.
The MC4 receptor and control of appetite.
The melanocortin agonist Melanotan-II reduces the orexigenic and adipogenic effects of neuropeptide Y (NPY) but does not affect the NPY-driven suppressive effects on the gonadotropic and somatotropic axes in the male rat.
(1991). The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain. Development
Thyroid transcription factor-1 facilitates cerebrospinal ﬂuid formation by regulating aquaporin-1 synthesis in the brain.
(1996). Thyroid-speciﬁc enhancer-binding protein Role in thyroid function and organogenesis. Trends Endocrinol Metab
TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-speciﬁc fashion.
TTF-1, a homeodomain-containing transcription factor, participates in the control of body ﬂuid homeostasis by regulating angiotensinogen gene transcription in the rat subfornical organ.
TTF-1, a homeodomain-containing transcription factor, regulates feeding behavior in the rat hypothalamus.