Article thumbnail

Learning From Glycosuria

By Ele Ferrannini
Topics: Commentaries
Publisher: American Diabetes Association
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (2009). a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus. Clin Pharmacol Ther
  2. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.
  3. Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial. Diabetes Care
  4. (2009). Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects. Clin Pharmacol Ther
  5. Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.
  6. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial.
  7. Effect of diabetes and insulin of the maximum capacity of the renal tubules to reabsorb glucose.
  8. (2009). Fiedorek FT. A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers: applicability of a novel insulin-independent treatment. Diabetes Care
  9. (2011). Functional expression of SGLTs in rat brain. Am J Physiol Cell Physiol 2010;299:C1277–C1284 FIG. 1. Renal glucose handling. Flux rates (filtration, reabsorption, and excretion) were calculated using a glomerular filtration rate of 120 mL
  10. Glucose transport by human renal
  11. (2005). Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes. Diabetes
  12. Inhibitor binding in the human renal low- and high-affinity Na+/glucose cotransporters.
  13. Maximum tubular reabsorption capacity for glucose and renal hemodynamics during rapid hypertonic glucose infusion in normal and diabetic subjects.
  14. Molecular analysis of the SGLT2 gene in patients with renal glucosuria.
  15. (1994). Molecular physiology of sodium-glucose cotransporters.
  16. Neuronal regulation of homeostasis by nutrient sensing.
  17. (2011). SGLT2 deletion improves glucose homeostasis and preserves pancreatic b-cell function. Diabetes
  18. SGLT2 mediates glucose reabsorption in the early proximal tubule.