(2002). A mixture model-based approach to the clustering of microarray expression data. Bioinformatics
(2007). A survey of genetic human cortical gene expression. Nature Genetics
(2000). Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder.
(2005). Barrett-Connor E: Bimodality of 2-h plasma glucose distributions in whites: the Rancho Bernardo study. Diabetes Care
(2004). Cheung VG: Genetic analysis of genome-wide variation in human gene expression. Nature
(2010). Comparison of scores for bimodality of gene expression distributions and genome-wide evaluation of the prognostic relevance of high-scoring genes.
(1995). Controlling the false discovery rate: a practical and powerful approach to multiple testing.
(2008). De Filippis EA, Mandarino LJ: Global relationship between the proteome and transcriptome of human skeletal muscle.
(2005). Endert PM: Concerted peptide Mason et al.
(2009). EP: Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis. Mol Immunol
(2008). et al: Genetics of gene expression and its effect on disease. Nature
(2007). Extracting three-way gene interactions from microarray data. Bioinformatics
(2004). F: A Model Based Background Adjustment for Oligonucleotide Expression Arrays.
Finch SJ: Mixture modeling of microarray gene expression data. BMC
(2003). Friend SH: Genetics of gene expression surveyed in maize, mouse and man. Nature
(2008). GA: Genome-Wide Gene Expression Signature of Environmental Geography in Leukocytes of Moroccan Amazighs. PLoS Genetics
(2002). Gene expression profile in skeletal muscle of type 2 diabetes and the effect of insulin treatment. Diabetes
(2010). Geographical genomics of human leukocyte gene expression variation in southern Morocco. Nature Genetics
(2003). Groop LC: PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nature Genetics
(1987). HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature
(2006). Houle S: Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression. Arch Gen Psychiatry
(1993). Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians.
(2010). Integrating pathway analysis and genetics of gene expression for genome-wide association studies.
(2009). JA: Global gene expression in skeletal muscle from well-trained strength and endurance athletes. Med Sci Sports Exerc
(2003). K: ACTN3 genotype is associated with human elite athletic performance.
(2000). Kadlubar FF: Quantitative analysis of interindividual variation of Glutathione S-Transferase expression in human pancreas and the ambiguity of correlating genotype with phenotype. Cancer Research
(2009). KR: The Bimodality Index: A Criterion for Discovering and Ranking Bimodal Signatures from Cancer Gene Expression Profiling Data. Cancer Informatics
(2003). LJ: Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci USA
(2002). MA: Bimodality in blood glucose distribution: is it universal? Diabetes Care
(2002). Microarray profiling of skeletal muscle tissues from equally obese, non-diabetic insulinsensitive and insulin-resistant Pima Indians. Diabetologia
(2007). Mixture modeling of transcript abundance classes in natural populations. Genome Biol
Nikolskaya T: Bimodal gene expression patterns in breast cancer. BMC Genomics 2010, 11(Suppl 1):S8.
(1987). On bootstrapping the likelihood ratio test statistic for the number of components in a normal mixture. Applied Statistics
(2006). Overlapping probabilities of top ranking gene lists, hypergeometric distribution, and stringency of gene selection criterion.
(2003). Permana PA: Identification of differentially expressed genes in skeletal muscle of non-diabetic insulinresistant and insulin-sensitive Pima Indians by differential display PCR. Diabetologia
(2002). Pooled analysis and meta-analysis of glutathione Stransferase M1 and bladder cancer: a HuGE review.
(1995). Ravussin E: Use of dual-energy X-ray absorptiometry in obese individuals.
(2006). SK: Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genetics
(2003). Speed TP: Exploration, Normalization, and Summaries of High Density Oligonucleotide Array Probe Level Data. Biostatistics
(2009). Subramaniam S: Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization. Proc Natl Acad Sci USA
(2008). Tozeren A: Expression profiles of switch-like genes accurately classify tissue and infectious disease phenotypes in model-based classification.
(2008). Tozeren A: Human and mouse switch-like genes share common transcriptional regulatory mechanisms for bimodality. BMC Genomics
(2008). Tozeren A: Switch-like genes populate cell communication pathways and are enriched for extracellular proteins.
(2008). Transcriptional profiling of myotubes from patients with type 2 diabetes: no evidence for a primary defect in oxidative phosphorylation genes. Diabetologia
(1977). Unexplained hyperinsulinemia in normal and “prediabetic” Pima Indians compared with normal Caucasians. An example of racial differences in insulin secretion. Diabetes
(2009). Vaag A: Gene expression in skeletal muscle biopsies from people with type 2 diabetes and relatives: differential regulation of insulin signaling pathways. PLoSOne
(2010). Wellcome Trust Case Control Consortium, Tyler-Smith
(2007). WO: A genome-wide association study of global gene expression. Nature Genetics
(1976). Yee S: Skewness in commingled distributions. Biometrics