Micofiltration is a mature process for separating particles from a solution. Fractionation, that is the separation of larger from smaller particles, is however more difficult, especially when the components to separate are not very different in size (1). In this chapter we evaluate the use of micro-engineered membranes for fractionation. These membranes or microsieves are a new type of membrane of which the pore size and geometery can be tailored to an extend that is unprecedented in 'regular' membranes. In the design of a fractionation process with microsieves necessarily we consider a wide range of size scales, from the very small dimension of one pore all the way up to module-scale fluid dynamics. In the conclusion section, the different scales are compared, and their importance for the actual fractionation process evaluate
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