Skip to main content
Article thumbnail
Location of Repository

Oral and transdermal estrogens both lower plasma total homocysteine in male-to-female transsexuals

By E.J. Giltay, P. Verhoef, L.J.G. Gooren, J.M. Geleijnse, E.G. Schouten and C.D.A. Stehouwer

Abstract

Plasma total homocysteine (tHcy) levels are on average lower in women versus men, indicating an estrogenic effect. Oral estrogens (absorbed via the liver) may be hypothesized to have stronger effects on hepatic homocysteine metabolism than transdermal estrogens. We randomly assigned 30 male-to-female transsexuals (20–44 years old) to 4 months’ administration of oral ethinyl estradiol (n=15) or transdermal 17ß-estradiol (n=15), both with the antiandrogen cyproterone acetate (CA). Ten other male controls were treated with CA only. At baseline and after 2 and 4 months, plasma tHcy was analyzed in conjunction with plasma folate. Oral ethinyl estradiol and transdermal 17ß-estradiol similarly reduced plasma tHcy (geometric mean 10.6 µmol/l [95% CI 8.2–13.9] to 7.5 [6.5; 8.8], and 11.3 [8.1; 16.4] to 8.4 [6.5; 11.1];

Year: 2003
OAI identifier:
Provided by: NARCIS
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.loc.gov/mods/v3 (external link)
  • http://library.wur.nl/oai (external link)
  • http://edepot.wur.nl/351323 (external link)
  • http://library.wur.nl/WebQuery... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.