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Toward the Synthesis and Biological Screening of a Cyclotetrapeptide from Marine Bacteria

By Rajiv Dahiya and Hemendra Gautam


The first synthesis of a naturally occurring tetrapeptide cyclo-(isoleucyl-prolyl-leucyl- alanyl) has been achieved using a solution-phase technique via coupling of dipeptide segments Boc-l-Pro-l-Leu-OH and l-Ala-l-Ile-OMe. Deprotection of the linear tetrapeptide unit and its subsequent cyclization gave a cyclopeptide, identical in all aspects to the naturally occurring compound. Bioactivity results indicated the antifungal and antihelmintic potential of the synthesized peptide against pathogenic dermatophytes and earthworms

Topics: Article
Publisher: Molecular Diversity Preservation International
OAI identifier: oai:pubmedcentral.nih.gov:3039471
Provided by: PubMed Central
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    3. (2003). A Novel Cyclopeptide from a Bacterium associated with the Marine Sponge Ircinia muscarum.
    4. (1963). Anthelmintic Activity of Myrsine africana.
    5. (1966). Antibiotic Susceptibility Testing by a Standardized Single Disk Method.
    6. (1993). Chemical Studies of Marine Bacteria: Developing a New Resource.
    7. (2005). Clonostachysins A and B, New Anti-dinoflagellate Cyclic Peptides from a Marine-derived Fungus.
    8. Cyclic Peptides as Novel Antineoplastic Agents: A Review.
    9. (2004). Cyclic Peptides from a Ruegeria strain of Bacteria associated with the Sponge Suberites
    10. (2005). Cyclic Peptides of the Nocardamine Class from a Marine-derived Bacterium of the Genus Streptomyces.
    11. (2006). Cyclic Peptides: New Hope for Antifungal Therapy.
    12. (2009). Cytotoxic and Antimicrobial Screening of a Proline-Rich Cyclopolypeptide.
    13. (2006). First Total Synthesis and Biological Screening of Hymenamide E. Acta Pharm.
    14. (2003). Marine Bacteria associated with Sponge as Source of Cyclic Peptides.
    15. (2003). Scytalidamides A and B, New Cytotoxic Cyclic Heptapeptides from a Marine Fungus of the Genus Scytalidium.
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    17. Synthetic and Pharmacological Studies on a Natural Cyclopeptide from Gypsophila arabica.
    18. (2007). Synthetic and Pharmacological Studies on Longicalycinin
    19. (2008). Synthetic Studies on a Cyclic Hexapeptide from Dianthus superbus.
    20. (1984). The Practice of Peptide Synthesis;
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