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Adhesive coatings based on melanin-like nanoparticles for surgical membranes

By Francesca Scognamiglio, Andrea Travan, Gianluca Turco, MASSIMILIANO ANTONIO Borgogna, Eleonora Marsich, Mattia Pasqua, Sergio Paoletti and Ivan Donati

Abstract

Adhesive coatings for implantable biomaterials can be designed to prevent material displacement from the site of implant. In this paper, a strategy based on the use of melanin-like nanoparticles (MNPs) for the development of adhesive coatings for polysaccharidic membranes was devised. MNPs were synthesized in vitro and characterized in terms of dimensions and surface potential, as a function of pH and ionic strength. The in vitro biocompatibility of MNPs was investigated on fibroblast cells, while the antimicrobial properties of MNPs in suspension were evaluated on E. coli and S. aureus cultures. The manufacturing of the adhesive coatings was carried out by spreading MNPs over the surface of polysaccharidic membranes; the adhesive properties of the nano-engineered coating to the target tissue (intestinal serosa) were studied in simulated physiological conditions. Overall, this study opens for novel approaches in the design of naturally inspired nanostructured adhesive systems

Topics: Bioadhesion, Bioinspired, Implantable biomaterials, Melanin-like nanoparticles (MNPs), Polysaccharides, Biotechnology, Surfaces and Interfaces, Physical and Theoretical Chemistry, Colloid and Surface Chemistry
Year: 2017
DOI identifier: 10.1016/j.colsurfb.2017.04.057
OAI identifier: oai:arts.units.it:11368/2903568
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