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Adjustment and Characterization of an Original Model of Chronic Ischemic Heart Failure in Pig

By Laurent Barandon, Joachim Calderon, Patricia Réant, Dominique Caillaud, Stéphane Lafitte, Xavier Roques, Thierry Couffinhal and Pierre Dos Santos

Abstract

We present and characterize an original experimental model to create a chronic ischemic heart failure in pig. Two ameroid constrictors were placed around the LAD and the circumflex artery. Two months after surgery, pigs presented a poor LV function associated with a severe mitral valve insufficiency. Echocardiography analysis showed substantial anomalies in radial and circumferential deformations, both on the anterior and lateral surface of the heart. These anomalies in function were coupled with anomalies of perfusion observed in echocardiography after injection of contrast medium. No demonstration of myocardial infarction was observed with histological analysis. Our findings suggest that we were able to create and to stabilize a chronic ischemic heart failure model in the pig. This model represents a useful tool for the development of new medical or surgical treatment in this field

Topics: Research Article
Publisher: SAGE-Hindawi Access to Research
OAI identifier: oai:pubmedcentral.nih.gov:2943114
Provided by: PubMed Central

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Citations

  1. (2009). Allogeneicmesenchymalstemcellsrestorecardiacfunctionin chronic ischemic cardiomyopathy via trilineage differentiating capacity,”
  2. (2006). An ovine model of chronic heart failure: echocardiographic and tissue Doppler imaging characterization,”
  3. (2008). and R.Sterz,“Thecostsoftreatingacuteheartfailure:aneconomic analysis of the SURVIVE trial,”
  4. (2009). Autologous mesenchymal stem cells produce reverse remodelling in chronic ischaemic cardiomyopathy,”
  5. (1997). Canty Jr., “18F-2-deoxyglucose deposition and regional flow in pigs with chronically dysfunctional myocardium: evidence for transmural variations in chronic hibernating myocardium,”
  6. (2008). Chronic ischemic mitral regurgitation induced in pigs by catheter-based coronary artery occlusion,”
  7. (2002). Contrast echocardiography can assess risk area and infarct size during coronary occlusion and reperfusion: experimental validation,”
  8. (2004). E a g l e ,R .A .G u y t o n ,R .D a v i d o ff et al., “ACC/AHA
  9. (2008). Embryonic stem cell therapy of heart failure in genetic cardiomyopathy,”
  10. (2008). Experimental validationofcircumferential,longitudinal,andradial2-dimensional strainduringdobutaminestressechocardiographyinischemic conditions,”
  11. (2007). F r i e d r i c ha n dJ .B o n a t t i ,“ H y b r i dc o r o n a r ya r t e r y revascularization—review and update
  12. (2009). focused update incorporated into the ACC/AHA
  13. (2009). G.deLissovoy,K.Fraeman,J.R.Teerlinketal.,“Hospitalcosts for treatment of acute heart failure: economic analysis of the REVIVE II study,”
  14. (2009). Hemodynamic changes in a model of chronic heart failure induced by multiple sequential coronary microembolization in sheep,”
  15. (2009). Influence of afterload on left ventricular radial and longitudinal systolic functions: a two-dimensional strain imaging study,”
  16. (2008). Intramyocardial transplantation of bone marrow-derived stem cells: ultrasonic strain rate imaging in a model of hibernating myocardium,”
  17. (2003). L.Barandon,T.Couffinhal,J.Ezanetal.,“Reductionofinfarct size and prevention of cardiac rupture in transgenic mice overexpressing
  18. (2005). Minimally invasive close-chest method for creating reperfused or occlusive myocardial infarction in swine,”
  19. (2009). Ovine models for chronic heart failure,”
  20. (2009). Zernecke et al., “Alteration of matrix metalloproteinases in selective left ventricular adriamycin-induced cardiomyopathy in the pig,”