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Basic Mechanisms of Arsenic Trioxide (ATO)-Induced Apoptosis in Human Leukemia (HL-60) Cells

By Clement Yedjou, Paul Tchounwou, John Jenkins and Robert McMurray
Topics: Research
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (2002). Accelerated apoptotic DNA laddering protocol. Biotechniques
  2. (1995). AH: Cell death in health and disease: the biology and regulation of apoptosis. Semin Cancer Biol
  3. (1995). Apoptosis, oncosis, and necrosis: an overview of cell death.
  4. (1998). Arsenic induces apoptosis in B-cell leukaemic cell lines in vitro: activation of caspases and down-regulation of Bcl-2 protein.
  5. (1999). Arsenic targets tubulins to induce apoptosis in myeloid leukemia cells. Cancer Res
  6. (1998). Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR a protein in acute promyelocytic leukemia cells.
  7. (1999). Arsenic trioxide induces apoptosis in neuroblastoma cell lines through the activation of caspase 3 in vitro. FEBS Lett
  8. (2003). Arsenic trioxide induces apoptosis in peripheral blood T lymphocyte subsets by inducing oxidative stress: a role of Bcl-2. Mol Cancer Ther
  9. (1999). Arsenic trioxide induces apoptosis of HPV16 DNA-immortalized human cervical epithelial cells and selectively inhibits viral gene expression.
  10. (1999). Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway. Blood
  11. (2009). Biological responses to arsenic compounds.
  12. (2000). Bootman MD: The versatility and universality of calcium signaling. Nat Rev Mol Cell Biol
  13. (2003). Cell death induced by acute renal injury: a perspective on the contributions of apoptosis and necrosis.
  14. (2002). CJ: Involvement of reactive oxygen species in arsenite-induced downregulation of phospholipid hydroperoxide glutathione peroxidase in human epidermoid carcinoma A431 cells. Free Radic Biol Med
  15. (1999). de Thé H: Arsenic trioxide and interferon- synergize to induce cell cycle arrest and apoptosis in human T-cell lymphotropic virus type I-transformed cells. Blood 1999, 93:278-273. Yedjou et al.
  16. (1994). Death from inside out: an overview.
  17. (1993). Eigenbrodt EH: Apoptosis and necrosis. Basic types and mechanisms of cell death. Arch Pathol Lab Med
  18. (2000). F: Flow cytometry detection of caspase 3 activation in preapoptotic leukemic cells. Cytometry
  19. (1999). Fermand JP: Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients. Cancer Res
  20. (1998). JK: Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis.
  21. (2000). Morphologic and biochemical hallmarks of apoptosis. Cardiovasc Res
  22. (2001). Necrotic volume increase and the early physiology of necrosis. Comp Biochem Physiol A
  23. (1994). Oers MH: Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood
  24. (1998). Pandolfi PP: Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML/RAR- independent manner. Blood
  25. (2005). PM: Arsenic trioxide mediates intrinsic and extrinsic pathways of apoptosis and cell cycle arrest in acute megakaryocytic leukemia.
  26. (1995). Reutelingsperger C: A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V.
  27. (1998). RP: Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide.
  28. (1996). SH: The role of proteases during apoptosis.
  29. (2002). SW: Apoptosis: a link between cancer genetics and chemotherapy. Cell
  30. (2010). Synergistic antiproliferative effect of arsenic trioxide combined with bortezomib in HL60 cell line and primary blasts from patients affected by myeloproliferative disorders. Cancer Genet Cytogenet
  31. (1997). Tatton WG: Mechanisms of nerve cell death: apoptosis or necrosis after cerebral ischemia. Int Rev Neurobiol
  32. (2009). Tchounwou PB: Arsenic trioxide-induced modulation of p53, c-fos, RARE, cyclin D1, and cyclin A in human leukemia (HL-60) cells. Mol Cell Biochem
  33. (2009). Tchounwou PB: Ascorbic acid potentiation of arsenic trioxide anticancer activity against acute promyelocytic leukemia. Archives of Drug Information
  34. (2008). Tchounwou PB: Differential effect of ascorbic acid and n-acetyl-l-cysteine on arsenic trioxide-mediated oxidative stress in human leukemia (HL-60) cells.
  35. (2006). Tchounwou PB: Dose and time-dependent response of human acute promyelocytic leukemia (HL-60) cells to arsenic trioxide treatment.
  36. (2007). Tchounwou PB: In vitro cytotoxic and genotoxic effects of arsenic trioxide on human leukemia (HL-60) cells using the MTT and alkaline single cell gel electrophoreis (comet) assays. Mol Cell Biochem
  37. (2006). Tchounwou PB: Oxidative stress in human leukemia (HL-60), human liver carcinoma (HepG2), and human Jurkat-T cells exposed to arsenic trioxide. Metal Ions Biol Med
  38. (1975). Therapeutic mule: the use of arsenic in the nineteenth century material medica. Pharmacy in History
  39. (2000). Tyers M: Transcriptional regulation: kamikaze activators. Curr Biol
  40. (1997). Wang ZY: Use of arsenic trioxide in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood
  41. (1992). XC: Ai-Lin 1 treated 32 cases of acute promyelocytic leukemia.
  42. (1996). XH: Arsenic trioxide treated 72 cases of acute promyelocytic leukemia.
  43. (2000). Ying DM: Arsenic trioxide induced apoptosis of the human B lymphoma cell line MBC-1. J Biol Regulat Homeost Agent
  44. (2000). YY: Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis. Cancer Res
  45. (1996). Z: In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR/PML proteins. Blood
  46. (2002). Zakeri Z: Caspase-independent cell deaths.

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