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Neuroprotection by S-PBN in hyperglycemic ischemic brain injury in rats

By Maria Molnar and Fredrik Lennmyr
Topics: Original Article
Publisher: Informa Healthcare
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Provided by: PubMed Central

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  4. (1988). Correlation of triphenyltetrazolium chloride perfusion staining with conventional neurohistology in the detection of early brain ischaemia. Neuropathol Appl Neurobiol.
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  7. (2005). Differential early mitogen-activated protein kinase activation in hyperglycemic ischemic brain injury in the rat. Eur J Clin Invest.
  8. (1991). Effect of plasma glucose on infarct size in focal cerebral ischemia-reperfusion.
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  11. (2005). Experimental treatment for focal hyperglycemic ischemic brain injury in the rat. Exp Brain Res.
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  13. (2003). Functional evaluation of cerebral microembolization in the rat. Brain Res.
  14. (2004). Hyperglycemia and hypercapnia differently affect post-ischemic changes in protein kinases and protein phosphorylation in the rat cingulate cortex. Brain Res.
  15. (1998). Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab.
  16. (1999). Increased oxidative stress brought on by proinflammatory cytokines in neurodegenerative processes and the protective role of nitrone-based free radical traps. Life Sci.
  17. (2007). Increased oxidative stress during hyperglycemic cerebral ischemia. Neurochem Int.
  18. (1996). Mechanisms of secondary brain injury.
  19. (1995). N-tert-butylalpha-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia.
  20. (2000). Neurological impairment in rats after transient middle cerebral artery occlusion: a comparative study under various treatment paradigms. Brain Res.
  21. (1993). Nitric oxide production during focal cerebral ischemia in rats.
  22. NXY-059 for acute ischemic stroke.
  23. NXY-059 for the treatment of acute ischemic stroke.
  24. On the analysis and interpretation of outcome measures in stroke clinical trials: lessons from the SAINT I study of NXY-059 for acute ischemic stroke.
  25. (2001). Phosphorylation of extracellular signal-regulated kinase after transient cerebral ischemia in hyperglycemic rats. Neurobiol Dis.
  26. Prevalence of admission hyperglycaemia across clinical subtypes of acute stroke.
  27. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.
  28. (2006). Regulation of cerebral glucose metabolism. Minerva Endocrinol.
  29. Reversible middle cerebral artery occlusion without craniectomy in rats.
  30. (1998). Stimulation of p42 and p44 mitogen-activated protein kinases by reactive oxygen species and nitric oxide in hippocampus.
  31. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview.
  32. T lymphocyte trafficking: a novel target for neuroprotection in traumatic brain injury.
  33. (1997). Uncoupling of local cerebral glucose metabolism and blood flow after acute fluid-percussion injury in rats.

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