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Whole organic electronic synapses for dopamine detection

By Martina Giordani, Michele DI LAURO, Marcello Berto, Carlo Augusto Bortolotti, Dominique Vuillaume, Henrique L. Gomes, Michele Zoli and Fabio Biscarini

Abstract

A whole organic artificial synapse has been fabricated by patterning PEDOT:PSS electrodes on PDMS that are biased in frequency to yield a STP response. The timescale of the STP response is shown to be sensitive to the concentration of dopamine, DA, a neurotransmitter relevant for monitoring the development of Parkinson's disease and potential locoregional therapies. The sensitivity of the sensor towards DA has been validated comparing signal variation in the presence of DA and its principal interfering agent, ascorbic acid, AA. The whole organic synapse is biocompatible, soft and flexible, and is attractive for implantable devices aimed to real-time monitoring of DA concentration in bodily fluids. This may open applications in chronic neurodegenerative diseases such as Parkinson's disease

Topics: Dopamine, Organic bioelectronics, PEDOT:PSS, STP, Synapse, Electronic, Optical and Magnetic Materials, Condensed Matter Physics, Computer Science Applications1707 Computer Vision and Pattern Recognition, Applied Mathematics, Electrical and Electronic Engineering
Publisher: 'SPIE-Intl Soc Optical Eng'
Year: 2016
DOI identifier: 10.1117/12.2239532
OAI identifier: oai:iris.unimore.it:11380/1136519

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