Article thumbnail

The PHD3 Domain of MLL Acts as a CYP33-Regulated Switch between MLL-Mediated Activation and Repression†,

By Sangho Park, Ute Osmers, Gayathree Raman, Rebecca H. Schwantes, Manuel O. Diaz and John H. Bushweller
Publisher: American Chemical Society
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (1994). 11q23 translocations split the “AT-hook” cruciform DNA-binding region andthetranscriptionalrepressiondomainfromtheactivationdomain of the mixed-lineage leukemia (MLL) gene. P r o c .N a t l .A c a d .S c i .U .
  2. (1996). A nuclear RNA-binding cyclophilin in human T cells.
  3. (2002). ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.
  4. (2006). and transcription at a subset of targeted ORFs.
  5. (2004). Automated NMR structure calculation with CYANA.
  6. (2000). Biological and therapeutic aspects of infant leukemia.
  7. (1993). Ch e n,C.S . ,S o r en s e n ,P.H . ,Do m e r ,P.H . ,R ea m a n ,G .H .,K o r s me y e r
  8. (2004). Charged gels as orienting media for measurement of residual dipolar couplings in soluble and integral membrane proteins.
  9. (1984). Conformational specificity of chymotrypsin toward proline-containing substrates.
  10. (1991). Determination of kinetic constants for peptidyl prolyl cis-trans isomerases by an improved spectrophotometric assay.
  11. (2007). DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA.
  12. (1995). Epipodophyllotoxin-related acute myeloid leukemia: A study of 35 cases.
  13. (2001). gene regulation in human cells.
  14. (2005). Genomic maps and comparative analysis of histone modifications in human and mouse.
  15. (1993). HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities.
  16. (2006). ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression.
  17. (2008). is necessary for MLL-ENL-induced hematopoietic stem cell immortalization.
  18. M.(2001)ThePolycombgroup: No longer an exclusive club?
  19. (1999). Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development.
  20. (2007). Methylation of lysine 4 on histone H3: Intricacy of writing and reading a single epigenetic mark.
  21. (2003). MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein.
  22. (2002). MLL targets SET domain methyltransferase activity to Hox gene promoters.
  23. (2001). MLL-ENL causes a reversible and mycdependent block of myelomonocytic cell differentiation.
  24. (2006). Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF.
  25. (2001). Molecular cloning, structure and expression of a novel nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain.
  26. (2006). Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2.
  27. (2008). PHD fingers in human diseases: Disorders arising from misinterpreting epigenetic marks.
  28. (2000). Prediction of sterically induced alignment in a dilute liquid crystalline phase: Aid to protein structure determination by NMR.
  29. (2006). Proline isomerization of histone H3 regulates lysine methylation and gene expression.
  30. (1999). Protein backbone angle restraints from searching a database for chemical shift and sequence homology.
  31. (1993). Quantitative J correlation: A new approach for measuring homonuclear three-bond J(HNHa) coupling constants in 15N-enriched proteins.
  32. (1993). Rearrangements involving chromosome band 11Q23 in acute leukaemia.
  33. (1993). Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA-topoisomerase II.
  34. (2007). Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression.
  35. (2010). Required for MLLDependent Gene Transcription.
  36. S.Y.,Landry, J.,Kauer,M.,Tackett,A.J.,Chait,B.T.,Badenhorst,P.,Wu,C.,and Allis,C.D.(2006)APHDfingerofNURFcoupleshistoneH3lysine4 trimethylation with chromatin remodelling.
  37. (2007). Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger.
  38. (2006). The APC tumor suppressor counteracts β-catenin activation and H3K4 methylation at Wnt target genes.
  39. (2008). The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression.
  40. (2005). The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  41. (2002). The MT domain of the protooncoprotein MLL binds to CpG-containing DNA and discriminates against methylation.
  42. (2008). The PHD fingers of MLL block MLL fusion protein-mediated transformation.
  43. (1998). Trithorax and the regulation of homeotic gene expressioninDrosophila:Ahistoricalperspective.Int.J.Dev.Biol.42,
  44. (1999). TROSY-based sequences for the measurement of 1HN15N, 15N13CO, 1HN13CO, 13CO13Caand 1HN13Ca dipolar couplings in 15N, 13C, 2H-labeled proteins.