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Human Antimicrobial Peptide LL-37 Induces MefE/Mel-Mediated Macrolide Resistance in Streptococcus pneumoniae▿

By Dorothea Zähner, Xiaoliu Zhou, Scott T. Chancey, Jan Pohl, William M. Shafer and David S. Stephens


Macrolide resistance is a major concern in the treatment of Streptococcus pneumoniae. Inducible macrolide resistance in this pneumococcus is mediated by the efflux pump MefE/Mel. We show here that the human antimicrobial peptide LL-37 induces the mefE promoter and confers resistance to erythromycin and LL-37. Such induction may impact the efficacy of host defenses and of macrolide-based treatment of pneumococcal disease

Topics: Mechanisms of Resistance
Publisher: American Society for Microbiology (ASM)
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Provided by: PubMed Central
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