Article thumbnail

Long term chemoradiotherapy-related dental and skeletal complications in a young female with nasopharyngeal carcinoma

By Ioulia Ioannidou-Marathiotou, Kyriaki Pistevou-Gompaki, Nikolaos Eleftheriadis and Christos Papaloukas


We describe the long-term complications six years after chemoradiotherapy in a 20-year old woman with nasopharyngeal carcinoma. We wanted to know whether the radiation dose was constant throughout the oral cavity, and thus uniformly affecting the corresponding dental and skeletal structures. Clinical and radiologic findings are described six years after chemoradiotherapy based on a two-dimensional computerized treatment planning system. This revealed radiation caries limited only to posterior teeth, proximal caries in the anterior teeth, limited but continuous salivary flow, mild periodontal infection, mild xerostomia, and a regenerative capacity of bones and the developmental process. The quantitative assessment of radiation delivered to the mandible revealed a high radiation dose in the posterior area and a minimal dose in the anterior area. This explains the differences in caries manifestation between the anterior and posterior teeth. According to the present study, individualized radiation fields, using a two-dimensional treatment planning system, result in restriction of severe damage of the dental and skeletal structures, which usually follows chemoradiotherapy. Orthodontic treatment could be initiated according to individual patient needs

Topics: Case Report
Publisher: Dove Medical Press
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. Case report of radiation injury of teeth and jaws.
  2. (1998). Craniofacial growth in children treated for malignant disease. Acta Odontol Scand.
  3. Dental and maxillofacial abnormalities in long term survivors of childhood cancer: Effects of treatment with chemotherapy and radiation to the head and neck.
  4. (2001). Nasopharyngeal carcinoma in childhood: Long term results of 32 patients. Radiother Oncol.
  5. (1989). Pediatric nasopharyngeal carcinoma: Long term follow up of 29 patients.
  6. Preradiation chemotherapy with methotrexate, cisplatin, 5-fluorouracil, and leucovorin for pediatric nasopharyngeal carcinoma.
  7. (2008). Radiation and chemotherapy combination for nasopharyngeal carcinoma in children: Radiotherapy dose adaptation after chemotherapy response to minimize late effects. Pediatr Blood Cancer.
  8. (1994). Radiationinduced hypoplasia of the teeth and mandible. A case report. Oral Surg Oral Med Oral Pathol.
  9. Trends in incidence and prognosis for head and neck cancer in the United States: A site-specific analysis of the SEER database.