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Gender Separation Increases Somatic Growth in Females but Does Not Affect Lifespan in Nothobranchius furzeri

By Michael Graf, Alessandro Cellerino and Christoph Englert

Abstract

According to life history theory, physiological and ecological traits and parameters influence an individual's life history and thus, ultimately, its lifespan. Mating and reproduction are costly activities, and in a variety of model organisms, a negative correlation of longevity and reproductive effort has been demonstrated. We are employing the annual killifish Nothobranchius furzeri as a vertebrate model for ageing. N. furzeri is the vertebrate displaying the shortest known lifespan in captivity with particular strains living only three to four months under optimal laboratory conditions. The animals show explosive growth, early sexual maturation and age-dependent physiological and behavioural decline. Here, we have used N. furzeri to investigate a potential reproduction-longevity trade-off in both sexes by means of gender separation. Though female reproductive effort and offspring investment were significantly reduced after separation, as investigated by analysis of clutch size, eggs in the ovaries and ovary mass, the energetic surplus was not reallocated towards somatic maintenance. In fact, a significant extension of lifespan could not be observed in either sex. This is despite the fact that separated females, but not males, grew significantly larger and heavier than the respective controls. Therefore, it remains elusive whether lifespan of an annual species evolved in periodically vanishing habitats can be prolonged on the cost of reproduction at all

Topics: Research Article
Publisher: Public Library of Science
OAI identifier: oai:pubmedcentral.nih.gov:2914755
Provided by: PubMed Central

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Citations

  1. (1989). A cost of mating in female fruitflies.
  2. (2002). A mortality cost of virginity at older ages in female Mediterranean fruit flies.
  3. (2009). Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila.
  4. (1980). An Experimental-Analysis of Reproductive Effort and Cost in the Japanese Medaka, Oryzias-Latipes.
  5. (2005). Annual fishes of the genus Nothobranchius as a model system for aging research.
  6. (2007). Cellerino A
  7. (2001). Comparative biology of aging in birds: an update.
  8. (2005). Cost of reproduction in Callosobruchus maculatus: effects of mating on male longevity and the effect of male mating status on female longevity.
  9. (2003). Costing reproduction.
  10. (1999). Costs and benefits of mating in the grasshopper Chorthippus parallelus (Caelifera: Acrididae).
  11. (1985). Costs of Reproduction - an Evaluation of the EmpiricalEvidence.
  12. (2009). Effects of dietary restriction on mortality and age-related phenotypes in the short-lived fish Nothobranchius furzeri.
  13. (1977). Evolution of ageing.
  14. (2004). GPOWER: Teststa ¨rkeanalysen leicht gemacht.
  15. (2009). High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research.
  16. (2008). Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri.
  17. (1989). Life history differences among the eutherian radiations.
  18. (2007). Lifespan is unrelated to investment in reproduction in populations of mammals and birds in captivity.
  19. (1993). Long-term cost of reproduction with and without accelerated senescence in Callosobruchus maculatus: analysis of age-specific mortality.
  20. (1973). Mating behavior, physical activity and aging in the housefly, Musca domestica.
  21. (1966). Natural Selection, the Costs of Reproduction, and a Refinement of Lack’s Principle. The American Naturalist 100: 687. Gender Separation
  22. (2008). Prachtgrundka ¨rpflinge. Marktheidenfeld: Deutsche Killifisch Gemeinschaft e.V.
  23. (1996). Regulation of somatic growth and the somatotropic axis by gonadal steroids: primary effect on insulinlike growth factor I gene expression and secretion.
  24. (2007). Reproduction and longevity: secrets revealed by C.
  25. (2006). Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate.
  26. (2005). Sex and Death: What Is the Connection?
  27. (2006). Sexual activity and reproduction delay ageing in a mammal.
  28. (2000). Tessier A
  29. (1988). The Ecological Context of Life History Evolution.
  30. (2005). The metabolic cost of egg production is repeatable.
  31. (1983). The Structure of Guppy Life Histories: The Tradeoff between Growth and Reproduction.
  32. (1989). Trade-Offs in Life-History Evolution.