Article thumbnail
Location of Repository

Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines

By Jeffery M Cowden, Jason P Riley, Jing Ying Ma, Robin L Thurmond and Paul J Dunford
Topics: Research
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. (2004). A Potent and Selective Histamine H4 Receptor Antagonist with Anti-Inflammatory Properties. J Pharmacol Exp Ther
  2. (2000). A: Effect of suplatast tosilate, a Th2 cytokine inhibitor, on steroiddependent asthma: a double-blind randomised study. Lancet
  3. (2001). Agosti JM: Efficacy of soluble IL-4 receptor for the treatment of adults with asthma.
  4. (2007). al: A Study to Evaluate Safety and Efficacy of Mepolizumab in Patients with Moderate Persistent Asthma. Am J Respir Crit Care Med
  5. (2005). AM: Therapeutic Dosing with Anti-Interleukin-13 Monoclonal Antibody Inhibits Asthma Progression in Mice. J Pharmacol Exp Ther
  6. (2006). BN: Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation.
  7. (2006). Caughey GH: Neutrophil histamine contributes to inflammation in mycoplasma pneumonia.
  8. (2002). CG: Airway and tissue mechanics in a murine model of asthma: alveolar capsule vs. forced oscillations.
  9. (2003). CG: Measuring lung function in mice: the phenotyping uncertainty principle.
  10. (1992). Daroczy B: Mechanical impedances of lungs and chest wall in the cat.
  11. (1998). DD: Interleukin-13: Central Mediator of Allergic Asthma.
  12. (2000). Djukanovic R: Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet
  13. (2005). Effect of suplatast tosilate on goblet cell metaplasia in patients with asthma. Allergy
  14. (2003). Effects of suplatast tosilate on allergic eosinophilic airway inflammation in patients with mild asthma.
  15. (1991). Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with increased airway obstruction. Am Rev Respir Dis
  16. (1999). Elias JA: Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production.
  17. (2010). et al: Chemokine Receptor 4 Plays a Key Role in T Cell Recruitment into the Airways of Asthmatic Patients.
  18. et al: The first potent and selective non-imidazole human histamine H4 receptor antagonists.
  19. (2006). EW: Importance of Myeloid Dendritic Cells in Persistent Airway Disease after Repeated Allergen Exposure. Am J Respir Crit Care Med
  20. (2008). Forssmann U: Intravascular inactivation of CCR5 by n-Nonanoyl-CC chemokine ligand 14 and inhibition of allergic airway inflammation.
  21. (2000). From Bronchoconstriction to Airways Inflammation and Remodeling. Am J Respir Crit Care Med
  22. (2007). Halayko AJ, Peng Z: Novel Recombinant Interleukin-13 Peptide-based Vaccine Reduces Airway Allergic Inflammatory Responses in Mice. Am J Respir Crit Care Med
  23. (2001). HK: Prolonged Antigen Exposure Ameliorates Airway Inflammation But Not Remodeling in a Mouse Model of Bronchial Asthma. Int Arch Allergy Appl Immunol
  24. (1987). Hunninghake G: Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with methacholine bronchial hyperresponsiveness.
  25. (1999). L: Interleukin-4 Receptor in Moderate Atopic Asthma. A Phase I/ II Randomized, Placebo-controlled Trial. Am J Respir Crit Care Med
  26. (2001). Lemanske RF: Asthma.
  27. (2007). Longphre M: Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. The Lancet
  28. (2008). NW: A Key Role for CC Chemokine Receptor 1 in T-Cell-Mediated Respiratory Inflammation.
  29. (2007). of 12FoxP3+ T Cells and Inhibits Allergic Asthma in a Murine Model.
  30. (2003). Pauwels RA: Effect of SCH55700, a Humanized AntiHuman Interleukin-5 Antibody, in Severe Persistent Asthma: A Pilot Study. Am J Respir Crit Care Med
  31. (2008). PJ: The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Nat Rev Drug Discov
  32. (2006). RL: The Histamine H4 Receptor Mediates Allergic Airway Inflammation by Regulating the Activation of CD4+ T Cells.
  33. (2000). SJ: Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice.
  34. (1996). SP U: T cells are the predominant source of interleukin-5 but not interleukin-4 mRNA expression in the lungs of antigen-challenged allergic mice.
  35. (2007). Vargaftig BB: Interference of methysergide, a specific 5-hydroxytryptamine receptor antagonist, with airway chronic allergic inflammation and remodelling in a murine model of asthma. Clinical & Experimental Allergy
  36. (2005). Werfel T: Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells.

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.