Alternative approaches can reduce the use of test animals under REACH. Addendum to the report “Assessment of additional testing needs under REACH. Effects of (Q)SARS, risk based testing and voluntary industry initiatives” .
(2008). Benfenati E: A New Hybrid QSAR Model for Predicting Bioconcentration Factor (BCF). Chemosphere
Bioconcentration of the Existing Chemical Substances.
CAESAR’s web site.
Calculator Plugin and Chemical Terms Demo.
(2008). External validation and prediction employing the predictive squared correlation coefficient -Lombardo et al.
(1996). Flow-through Fish Test. Organisation for Economic Cooperation and Development
(2009). Globally Harmonized System classification and labelling of chemicals (GHS). Third revised edition. United Nations
(2006). Gobas FAPC: A review of bioconcentration factor (BCF) and bioaccumulation factor (BAF) assessments for organic chemicals in aquatic organisms. Environ Rev
(1997). Improved Method for Estimating Bioconcentration Factor (BCF) from OctanolWater Partition Coefficient.
Java download web site.
(2005). Mekenyan O: Base-line model for identifying the bioaccumulation potential of chemicals.
(2008). No 1272/2008 of the European Parliament and of the
(2006). No 1907/2006 of the European Parliament and of the Council of 18
Re-Evaluation of Animal Numbers and Costs for In Vivo Tests to Accomplish REACH Legislation Requirements for Chemicals - a Report by the Transatlantic Think Tank for Toxicology (t4)*. Altex 26:3/09.
(1999). S: Improved Method for Estimating Bioconcentration/Bioaccumulation Factor from Octanol/Water Partition Coefficient. Environ Toxicol Chem