Article thumbnail
Location of Repository

APP Intracellular Domain Impairs Adult Neurogenesis in Transgenic Mice by Inducing Neuroinflammation

By Kaushik Ghosal, Andrea Stathopoulos and Sanjay W. Pimplikar
Topics: Research Article
Publisher: Public Library of Science
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. (2005). A role for adult neurogenesis in spatial long-term memory.
  2. (2008). A role for adult TLXpositive neural stem cells in learning and behaviour.
  3. (2001). A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.
  4. (2001). A transcriptionally [correction of transcriptively] active complex
  5. (2007). Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer’s disease.
  6. (2006). Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology.
  7. (2009). Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain. Neurobiol Aging.
  8. (2005). Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain.
  9. (2007). Adult hippocampal neurogenesis and aging.
  10. (1994). Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus.
  11. (2008). Adult neurogenesis, neuroinflammation and therapeutic potential of adult neural stem cells.
  12. (2010). Aging and excitotoxic stress exacerbate neural circuit reorganization in amyloid precursor protein intracellular domain transgenic mice. Neurobiol Aging;doi:10.1016/j.neurobiolaging.2010.04.020.
  13. Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer’s disease.
  14. (2009). Alzheimer’s disease-like pathological features in transgenic mice expressing the APP intracellular domain.
  15. (1998). Alzheimer’s disease: genetic studies and transgenic models.
  16. (2008). Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice.
  17. (1999). Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice.
  18. (2008). Amyloid-beta protein dimers isolated directly from Alzheimer’s brains impair synaptic plasticity and memory.
  19. (1995). beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity.
  20. (2003). C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.
  21. (2007). Classification and prediction of clinical Alzheimer’s diagnosis based on plasma signaling proteins.
  22. (2006). Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer’s disease.
  23. (2002). Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer’s disease.
  24. (2003). Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice.
  25. (2004). Enhanced neurogenesis in Alzheimer’s disease transgenic (PDGF-APPSw,Ind) mice.
  26. (2002). Functional neurogenesis in the adult hippocampus.
  27. (2000). Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer’s amyloid beta protein precursor.
  28. (1997). Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampusbased long-term memory.
  29. (2009). GSK-3 is a master regulator of neural progenitor homeostasis.
  30. (2009). Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer’s Disease.
  31. (2009). Immune activation in brain aging and neurodegeneration: too much or too little?
  32. (2008). Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer’s disease.
  33. Impaired neurogenesis is an early event in the etiology of familial Alzheimer’s disease in transgenic mice.
  34. Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders.
  35. (2003). Inflammatory blockade restores adult hippocampal neurogenesis.
  36. (2009). Interruption of beta-catenin signaling reduces neurogenesis in Alzheimer’s disease.
  37. (2008). Linking Abeta and tau in late-onset Alzheimer’s disease: a dual pathway hypothesis.
  38. (2008). Mechanisms and functional implications of adult neurogenesis.
  39. Mechanisms underlying inflammation in neurodegeneration.
  40. (2009). Neurogenesis and Alzheimer’s disease: At the crossroads. Exp Neurol.
  41. (2001). Neurogenesis in the adult is involved in the formation of trace memories.
  42. (2008). Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation.
  43. (2001). Nonsteroidal antiinflammatory drugs and the risk of Alzheimer’s disease.
  44. (2009). Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway.
  45. (2006). Potential role for adult neurogenesis in the encoding of time in new memories.
  46. (2009). Reassessing the amyloid cascade hypothesis of Alzheimer’s disease.
  47. (2002). The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics.
  48. (2001). The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus.

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.