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Metabolite Profiling of LADA Challenges the View of a Metabolically Distinct Subtype

By Mahmoud Al-Majdoub, Arslan Ali, Petter Storm, Anders H. Rosengren, Leif Groop and Peter Spegel

Abstract

Latent autoimmune diabetes in adults (LADA) usually refers to GAD65 autoantibodies (GADAb)-positive diabetes with onset after 35 years of age and no insulin treatment within the first 6 months after diagnosis. However, it is not always easy to distinguish LADA fromtype 1 or type 2 diabetes. In this study, we examined whether metabolite profiling could help to distinguish LADA (n = 50) from type 1 diabetes (n = 50) and type 2 diabetes (n = 50). Of 123 identified metabolites, 99 differed between the diabetes types. However, no unique metabolite profile could be identified for any of the types. Instead, the metabolome varied along a C-peptide-driven continuum from type 1 diabetes via LADA to type 2 diabetes. LADA was more similar to type 2 diabetes than to type 1 diabetes. In a principal component analysis, LADA patients overlapping with type 1 diabetes progressed faster to insulin therapy than those overlapping with type 2 diabetes. In conclusion, we could not find any unique metabolite profile distinguishing LADA from type 1 and type 2 diabetes. Rather, LADA was metabolically an intermediate of type 1 and type 2 diabetes, with those patients closer to the former showing a faster progression to insulin therapy than those closer to the latter

Topics: GLUTAMIC-ACID DECARBOXYLASE, INSULIN-RESISTANCE, RISK-FACTORS, DISEASE, PLASMA, ANTIBODIES, IDENTIFICATION, HOMOCYSTEINE, DIAGNOSIS, CYSTEINE, 3121 Internal medicine, GLUTAMIC-ACID DECARBOXYLASE, INSULIN-RESISTANCE, RISK-FACTORS, DISEASE, PLASMA, ANTIBODIES, IDENTIFICATION, HOMOCYSTEINE, DIAGNOSIS, CYSTEINE, 3121 Internal medicine
Publisher: American Diabetes Association
Year: 2017
OAI identifier: oai:helda.helsinki.fi:10138/178880
Journal:

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