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CFTR-Adenylyl Cyclase I Association Responsible for UTP Activation of CFTR in Well-Differentiated Primary Human Bronchial Cell Cultures

By Wan Namkung, Walter E. Finkbeiner and A. S. Verkman


We found that UTP-induced cystic fibrosis transmembrane conductance regulator activation is primarily mediated by cAMP signaling through activation of AC1 by calcium elevation, indicating major cross-talk between calcium and cAMP signaling pathway in human bronchial epithelial cells

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Publisher: The American Society for Cell Biology
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Provided by: PubMed Central
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