Article thumbnail
Location of Repository

Capsaicin Inhibits the Spontaneous Pacemaker Activity in Interstitial Cells of Cajal From the Small Intestine of Mouse

By Seok Choi, Jae Myeong Sun, Pawan Kumar Shahi, Dong Chuan Zuo, Hyun Il Kim and Jae Yeoul Jun
Topics: Original Article
Publisher: Korean Society of Neurogastroenterology and Motility
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. (2010). A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract.
  2. (1993). Amplification of nitric oxide signaling by interstitial cells isolated from canine colon.
  3. Block effect of capsaicin on hERG potassium currents is enhanced by S6 mutation at Y652.
  4. (1987). Calcitonin gene-related peptide (CGRP) in capsaicin-sensitive substance P-immunoreactive sensory neurons in animals and man: distribution and release by capsaicin. Peptides
  5. Calcium oscillation linked to pacemaking of interstitial cells of Cajal: requirement of calcium influx and localization of TRP4 in caveolae.
  6. Capsaicin inhibits in vitro and in vivo angiogenesis.
  7. (1991). Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol Rev
  8. (1990). Direct evidence for the involvement of vasoactive intestinal polypeptide in the motor response of the human isolated ileum to capsaicin.
  9. Distribution of the vanilloid receptor (VR1) in the gastrointestinal tract.
  10. (2001). Effects of capsaicin on human intestinal cell line Caco-2. Cytotechnology
  11. Effects of capsaicin on visceral smooth muscle: a valuable tool for sensory neurotransmitter identification.
  12. Efficacy of pharmacological treatments of neuropathic pain: an update and effect related to mechanism of drug action. Pain 1999;83:389-400. 2 . T o m i n a g a M , T o m i n a g a T . S t r u c t u r e a n d f u n c t i o n o f
  13. (1992). Endogenous nitric oxide and sensory neuropeptides interact in the modulation of the rat gastric microcirculation.
  14. Evidence that the contractile response of the guinea-pig ileum to capsaicin is due to release of substance P.
  15. Interstitial cells of Cajal and GI motility.
  16. Involvement of capsaicin-sensitive sensory nerves in gastric adaptive relaxation in isolated guinea-pig stomachs.
  17. (1990). Motor response of the human isolated colon to capsaicin and its relationship to release of vasoactive intestinal polypeptide.
  18. (1994). Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine.
  19. (2002). Nitric oxide is involved in the relaxant effect of capsaicin in the human sigmoid colon circular muscle. Naunyn Schmiedebergs Arch Pharmacol
  20. (1999). Novel natural vanilloid receptor agonists: new therapeutic targets for drug development. Trends Pharmacol Sci
  21. Pacemaking in interstitial cells of Cajal depends upon calcium handling by endoplasmic reticulum and mitochondria.
  22. Pathway-specific patterns of the co-existence of substance P, calcitonin gene-related peptide, cholecystokinin and dynorphin in neurons of the dorsal root ganglia of the guinea-pig.
  23. Peripheral TRPV1 receptors as targets for drug development: new molecules and mechanisms.
  24. (1998). Physiological features of visceral smooth muscle cells, with special reference to receptors and ion channels. Physiol Rev
  25. Properties of gastric smooth muscles obtained from mice which lack inositol triphosphate receptor.
  26. Protective role of vanilloid receptor type 1 in HCl-induced gastric mucosal lesions in rats.
  27. Regulaton of pacemaker currents in interstitial cells of Cajal from murine small intestine by cyclic nucleotides.
  28. Spontaneous electrical activity of interstitial cells of Cajal isolated from canine proximal colon.
  29. (1998). Spontaneous electrical rhythmicity in cultured interstitial cells of Cajal from the murine small intestine.
  30. The emerging role of TRPV1 in diabetes and obesity.
  31. (1995). The inhibitory modulation of guinea-pig intestinal peristalsis caused by capsaicin involves calcitonin gene-related peptide and nitric oxide. Naunyn Schmiedebergs Arch Pharmacol
  32. (1986). The neuropharmacology of capsaicin: review of some recent observations. Pharmacol Rev
  33. The relationship of TRP channels to the pacemaker activity of interstitial cells of Cajal in the gastrointestinal tract.
  34. Vanilloid receptor (VR1) expression in vagal afferent neurons innervating the gastrointestinal tract.
  35. (2004). Vanilloid receptor type-1 immunoreactivities in the mouse myenteric plexus: Immunohistochemical and electrophysiological study.
  36. (1995). W/kit gene required for intestinal pacemaker activity.

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.