Article thumbnail

Acceptable outcome following resection of bilateral large popliteal space heterotopic ossification masses in a spinal cord injured patient: a case report

By Ramin Espandar and Babak Haghpanah


Spinal cord injury is a well-known predisposing factor for development of heterotopic ossification around the joints especially hip and elbow. Heterotopic ossification about the knee is usually located medially, laterally or anteriorly; besides, the knee is generally fixed in flexion. There are only a few reports of heterotopic bone formation at the posterior aspect of the knee (popliteal space) and fixation of both knees in extension; so, there is little experience in operative management of such a problem

Topics: Case Report
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (1991). A clinical perspective on common forms of acquired heterotopic ossification. Clin Orthop Relat Res
  2. (1999). BF: Functional outcome of excision of heterotopic ossification after total hip arthroplasty. Clin Orthop Relat Res
  3. (2006). Blumen N: Heterotopic ossification in Guillain-Barre syndrome: incidence and effects on functional outcome with long-term follow-up. Arch Phys Med Rehabil
  4. (2002). Brain injury-related heterotopic bone formation: treatment strategy and results.
  5. (2004). EM: Heterotopic ossification.
  6. (1999). Excision for the treatment of periarticular ossification of the knee in patients who have a traumatic brain injury. J Bone Joint Surg Am
  7. (2005). Excision of heterotopic ossification from the knee: a functional outcome study. Clin Orthop Relat Res
  8. (2000). Fibrodysplasia ossificans progressiva, a heritable disorder of severe heterotopic ossification, maps to human chromosome 4q27-31. Am J Hum Genet
  9. (1999). Fratkin MJ: Impact of clinically significant heterotopic ossification on functional outcome after traumatic brain injury. J Head Trauma Rehabil
  10. (2003). FS: Paresis of a bone morphogenetic protein-antagonist response in a genetic disorder of heterotopic skeletogenesis.
  11. (1993). FS: The natural history of heterotopic ossification in patients who have fibrodysplasia ossificans progressiva. A study of forty-four patients.
  12. (1993). Functional outcome following surgical excision of heterotopic ossification in patients with traumatic brain injury.
  13. (2005). Heterotopic ossification: a review. J Rehabil Med
  14. (2006). Heterotopic ossification: Pathophysiology, clinical features, and the role of radiotherapy for prophylaxis. Int J Radiat Oncol Biol Phys
  15. (2002). Jr: Bone morphogenetic proteins with some comments on fibrodysplasia ossificans progressiva and NOGGIN.
  16. (2005). Koelbl O: The influence of heterotopic ossification on functional status of hip joint following total hip arthroplasty. Strahlenther Onkol
  17. (2007). Lagarde JP: Mutations of the noggin and of the activin A type I receptor genes in fibrodysplasia ossificans progressiva (FOP). Genet Couns
  18. (2004). Lais RL: Excision of heterotopic ossification of the popliteal space following traumatic brain injury.
  19. (2005). Lucotte G: A new mutation of the noggin gene in a French Fibrodysplasia ossificans progressiva (FOP) family. Genet Couns
  20. (2007). ML: The prophylaxis and treatment of heterotopic ossification following lower limb arthroplasty. J Bone Joint Surg Br
  21. (1996). Mollaret O: Excision of heterotopic ossification around the knee following brain injury. Injury
  22. (2009). Mutations of the noggin (NOG) and of the activin A type I receptor (ACVR1) genes in a series of twenty-seven French fibrodysplasia ossificans progressiva (FOP) patients. Genet Couns
  23. (1975). Observations on the induction of bone in soft tissues.
  24. (1980). RL: Periarticular heterotopic ossification in head-injured adults. Incidence and location.
  25. (2008). Xenakis TA: Functional outcome after excision of heterotopic ossification about the knee in ICU patients. Int Orthop
  26. (1999). Yotis CL: Ankylosed hips caused by heterotopic ossification after traumatic brain injury: a difficult problem.