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Clinical significance of the expression of connexin26 in colorectal cancer

By Shinya Nomura, Kiyoshi Maeda, Eiji Noda, Toru Inoue, Shinya Fukunaga, Hisashi Nagahara and Kosei Hirakawa
Topics: Research
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (1995). Aberrant expression of gap junction proteins (connexins) is associated with tumor progression during multistage mouse skin carcinogenesis in vivo. Carcinogenesis
  2. (1994). Altered homologous and heterologous gap-junctional intercellular communication in primary human liver tumors associated with aberrant protein localization but not gene mutation of connexin 32.
  3. (2001). Apoptosis as an independent prognostic indicator in squamous cell carcinoma of the esophagus. Pathol Int
  4. (2005). Connexin 26 correlates with Bcl-xL and Bax proteins expression in colorectal cancer.
  5. (2009). Correlation between connexin 26 expression and poor prognosis of esophageal squamous cell carcinoma. Ann Surg Oncol
  6. (1995). de Velde CJ, Melief CJ: Antibodies against p53 are associated with poor prognosis of colorectal cancer.
  7. (1995). DR: p53 point mutation and survival in colorectal cancer patients. Cancer Res
  8. (2006). DW: Connexins act as tumor suppressors in three-dimensional mammary cell organoids by regulating differentiation and angiogenesis. Cancer Res
  9. (2003). Enomoto K: Connexin26-mediated gap junctional communication reverses the malignant phenotype of MCF-7 breast cancer cells. Cancer Sci
  10. (1996). et al.: p21/WAF1 cyclin-kinase inhibitor expression in non-Hodgkin's lymphomas: a potential marker of p53 tumor-suppressor gene function. Blood
  11. (1996). Gilula NB: The gap junction communication channel. Cell
  12. (2005). I: Immunoprofiles of 11 biomarkers using tissue microarrays identify prognostic subgroups in colorectal cancer. Neoplasia
  13. (2006). Increased expression of connexin 26 in the invasive component of lung squamous cell carcinoma: significant correlation with poor prognosis. Cancer Lett
  14. (2008). Lim SC: Pathological significance of connexin 26 expression in colorectal adenocarcinoma. Oncol Rep
  15. (1995). Malagelada JR: Induction of nitric oxide synthase in colonic smooth muscle from patients with toxic megacolon. Gastroenterology
  16. (1998). Marumo F: Expression of connexin32 and connexin43 gap junction proteins and E-cadherin in human lung cancer. Cancer Lett
  17. (1992). MJ: Intercellular calcium signaling via gap junctions in glioma cells.
  18. (2000). Nojima H: A role for heterologous gap junctions between melanoma and endothelial cells in metastasis.
  19. (1992). p53, guardian of the genome.
  20. (1996). Reduced connexin 43 expression in high grade, human prostatic adenocarcinoma cells. Biochem Biophys Res Commun
  21. (2007). S: Connexin26 expression is associated with lymphatic vessel invasion and poor prognosis in human breast cancer. Breast Cancer Res Treat
  22. (2002). SK: Growth inhibition by connexin26 expression in cultured rodent tumor cells. Mol Cells
  23. (2002). Structural and functional diversity of connexin genes in the mouse and human genome. Biol Chem
  24. (2005). Sulkowska M: Alterations in connexin26 expression during colorectal carcinogenesis. Oncology
  25. (2008). Takemasa I, et al.: Aberrant expression of connexin 26 is associated with lung metastasis of colorectal cancer. Clin Cancer Res
  26. (1994). Thomas G: Association of p53 mutations with short survival in colorectal cancer. Gastroenterology
  27. (2004). Willecke K: Gap junctions and the connexin protein family. Cardiovasc Res