Article thumbnail

The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition

By David S Yee, Yaxiong Tang, Xuesen Li, Zhongbo Liu, Yi Guo, Samia Ghaffar, Peter McQueen, Dash Atreya, Jun Xie, Anne R Simoneau, Bang H Hoang and Xiaolin Zi
Topics: Research
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (1997). A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci USA
  2. (2010). A: Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase. Oncogene
  3. (2003). AM: Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation. Cancer Res
  4. (2010). Amadori D: Pathogenesis of osteoblastic bone metastases from prostate cancer. Cancer
  5. (2004). Baylin SB: Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet
  6. (2008). Bhowmick NA: Prostate tumor progression is mediated by a paracrine TGF-beta/Wnt3a signaling axis. Oncogene
  7. (2009). Bhowmick NA: Urothelial transdifferentiation to prostate epithelia is mediated by paracrine TGF-beta signaling. Differentiation
  8. (2009). C: Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinoma. Cancer Res
  9. (2010). Chemical genomic screening for methylation-silenced genes in gastric cancer Received:
  10. (2007). Corey E: When prostate cancer meets bone: control by wnts. Cancer Lett
  11. (2009). CS: Wnt inhibitory factor (WIF)-1 inhibits osteoblastic differentiation in mouse embryonic mesenchymal cells. Bone
  12. (2009). Dahiya R: Functional significance of Wnt inhibitory factor-1 gene in kidney cancer. Cancer Res
  13. (1997). De Robertis EM: Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Cell
  14. (2008). Dey A: Wnt signaling and cancer development: therapeutic implication. Neoplasma
  15. (2008). DM: Androgen-induced programs for prostate epithelial growth and invasion arise in embryogenesis and are reactivated in cancer. Oncogene
  16. (2007). DM: Inducible FGFR-1 activation leads to irreversible prostate adenocarcinoma and an epithelial-tomesenchymal transition. Cancer Cell
  17. (2001). E: Cloning and characterization of three Xenopus Slug promoters reveal direct regulation by Lef/β-catenin signaling.
  18. (2006). Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway. Clin Cancer Res
  19. (2004). Epithelial-mesenchymal transitions: twist in development and metastasis. Cell
  20. (2002). ER: Cadherin and catenin alterations in human cancer. Genes Chromosomes Cancer
  21. (2006). ET: The role of Wnts in bone metastases. Cancer Metastasis Rev
  22. (2001). Feldman D: The development of androgen-independent prostate cancer. Nat Rev Cancer
  23. (2005). Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. Cancer Res
  24. (2009). frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell
  25. (1999). Hendrix MJ: Suppression of prostate cancer invasive potential and matrix metalloproteinase activity by E-cadherin transfection. Cancer Res
  26. (2005). Hoang BH: Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness. Cancer Res
  27. (2010). Hoang BH: Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma. Mol Cancer Ther
  28. (2010). Hsieh JT: Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. Proc Natl Acad Sci USA
  29. (2007). Hughes CC: Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. Immunity
  30. (2005). Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells. Prostate
  31. (2004). Jablons DM: Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer. Cancer Res
  32. (2006). Jablons DM: Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma. Biochem Biophys Res Commun
  33. (2006). Jablons DM: Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines. Biochem Biophys Res Commun
  34. (2006). KD: Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer. Carcinogenesis
  35. (2010). Kypta RM: Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells. Mol Cancer
  36. (1998). Niehrs C: Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction.
  37. (2003). Pilarsky C: WIF1, a component of the Wnt pathway, is downregulated in prostate, breast, lung, and bladder cancer.
  38. (2004). SA: An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells. Cancer Cell
  39. (2002). Strongin AY: Promoter characterization of the novel human matrix metalloproteinase-26 gene: regulation by the T-cell factor-4 implies specific expression of the gene in cancer cells of epithelial origin.
  40. The Wnt Homepage
  41. (2009). Thomas DM: Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice.
  42. (2009). Thun MJ: Cancer statistics,
  43. (2009). Vascular morphogenesis: a Wnt for every vessel? Curr Opin Genet Dev
  44. (1996). Vukicevic S, Luyten FP: Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis.
  45. (2009). Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesis.