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Lens Fiber Cell Differentiation and Denucleation Are Disrupted through Expression of the N-Terminal Nuclear Receptor Box of Ncoa6 and Result in p53-dependent and p53-independent Apoptosis

By Wei-Lin Wang, Qingtian Li, Jianming Xu and Aleš Cvekl

Abstract

Lens fiber cell differentiation, denucleation, and abnormal apoptosis were examined through lens-specific expression of the N-terminal nuclear receptor box of NCOA6 in combination with lens-specific deletion of Ncoa6 in mice. The present data show that early apoptosis in lens fiber cells inhibits their subsequent denucleation

Topics: Articles
Publisher: The American Society for Cell Biology
OAI identifier: oai:pubmedcentral.nih.gov:2903674
Provided by: PubMed Central
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