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ADP-Ribosylation Factor 6 Regulates Mammalian Myoblast Fusion through Phospholipase D1 and Phosphatidylinositol 4,5-Bisphosphate Signaling Pathways

By Anne-Sophie Bach, Sandrine Enjalbert, Franck Comunale, Stéphane Bodin, Nicolas Vitale, Sophie Charrasse and Cécile Gauthier-Rouvière


Here we show that ARF6 is associated with the multiproteic complex that contains M-cadherin, Trio, and Rac1 and accumulates at sites of myoblast fusion. ARF6 silencing inhibits the association of Trio and Rac1 with M-cadherin. Moreover, we demonstrate that ARF6 regulates myoblast fusion through Phospholipase D activation and PI(4,5)P2 production

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Publisher: The American Society for Cell Biology
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