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Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance

By Anne F Gasasira, Moses R Kamya, Edwin O Ochong, Neil Vora, Jane Achan, Edwin Charlebois, Theodore Ruel, Fredrick Kateera, Denise N Meya, Diane Havlir, Philip J Rosenthal and Grant Dorsey
Topics: Research
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (2009). 4:e4569. doi: 10.1186/1475-2875-9-177 Cite this article as: Gasasira et al., Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance Malaria Journal
  2. (2006). AA: Antifolate resistance in Plasmodium falciparum: multiple origins and identification of novel dhfr alleles. J Infect Dis
  3. (2007). AA: Common origin and fixation of Plasmodium falciparum dhfr and dhps mutations associated with sulfadoxine-pyrimethamine resistance in a low-transmission area in South America. Antimicrob Agents Chemother
  4. (2003). AM: Prediction of Plasmodium falciparum resistance to sulfadoxine/pyrimethamine in vivo by mutations in the dihydrofolate reductase and dihydropteroate synthetase genes: a comparative study between sites of differing endemicity.
  5. (2006). Artesunate + amodiaquine and artesunate + sulphadoxinepyrimethamine for treatment of uncomplicated malaria in Democratic Republic of Congo: a clinical trial with determination of sulphadoxine and pyrimethamine-resistant haplotypes. Trop Med Int Health
  6. (2008). C: Emergence of a dhfr Mutation Conferring HighLevel Drug Resistance in Plasmodium falciparum Populations from Southwest Uganda. J Infect Dis
  7. (2005). Chaluluka E, Meshnick SR: Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi. Antimicrob Agents Chemother
  8. Chandramohan D: High resistance of Plasmodium falciparum to sulphadoxine/pyrimethamine in northern Tanzania and the emergence of dhps resistance mutation at Codon
  9. (2007). Children and AIDS: a stocktaking report
  10. (2005). CV: Impact of trimethoprim-sulfamethoxazole prophylaxis on falciparum malaria infection and disease.
  11. (1997). CV: The efficacy of antifolate antimalarial combinations in Africa: a predictive model based on pharmacodynamic and pharmacokinetic analyses. Parasitol Today
  12. (1998). DC: Plasmodium falciparum: detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion. Exp Parasitol
  13. (1999). Early chemoprophylaxis with trimethoprimsulphamethoxazole for HIV-1-infected adults in Abidjan, Côte d'Ivoire: a randomised trial. Cotrimo-CI Study Group. Lancet
  14. (2007). Effects of trimethoprimsulfamethoxazole and insecticide-treated bednets on malaria among HIV-infected Ugandan children. AIDS
  15. (2007). F: Therapeutic efficacy of sulfadoxine-pyrimethamine and the prevalence of molecular markers of resistance in under 5-year olds in Brazzaville, Congo. Trop Med Int Health
  16. (2006). G: Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance.
  17. (2006). G: Longitudinal study of urban malaria in a cohort of Ugandan children: description of study site, census and recruitment.
  18. (1999). Greenberg AE: Efficacy of trimethoprim-sulphamethoxazole prophylaxis to decrease morbidity and mortality in HIV-1-infected patients with tuberculosis in Abidjan, Côte d'Ivoire: a randomised controlled trial. Lancet
  19. (2006). Gulmezoglu AM: Drugs for preventing malaria in pregnant women. Cochrane Database Syst Rev
  20. (2003). Health U: Uganda National Antiretroviral Treatment and Care Guidelines for Adults and Children
  21. (1994). JE: Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine.
  22. (1993). KN: High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Mol Biochem Parasitol
  23. (2007). Malaria incidence and efficacy of intermittent preventive treatment in infants (IPTi).
  24. (2001). Nzila AM: Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next? Trends Parasitol
  25. (2005). Plowe CV: Mechanisms of resistance of malaria parasites to antifolates. Pharmacol Rev
  26. (1995). Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa. Am J Trop Med Hyg
  27. (2007). SJ: Effect of sulfadoxine-pyrimethamine resistance on the efficacy of intermittent preventive therapy for malaria control during pregnancy: a systematic review. JAMA
  28. (2006). Solberg P: Effect of co-trimoxazole prophylaxis, antiretroviral therapy, and insecticide-treated bednets on the frequency of malaria in HIV-1-infected adults in Uganda: a prospective cohort study. Lancet
  29. (2010). This article is available from: ©
  30. (2006). Validation of microsatellite markers for use in genotyping polyclonal Plasmodium falciparum infections. Am J Trop Med Hyg
  31. (2006). WHO: Guidelines on co-trimoxazole prophylaxis for HIV-related infections among children, adolescents and adults. Recommendations for a public health approach
  32. (2005). Why has the dihydrofolate reductase 164 mutation not consistently been found in Africa yet? Trans R Soc Trop Med Hyg