Article thumbnail

Characterization of the equine skeletal muscle transcriptome identifies novel functional responses to exercise training

By Beatrice A McGivney, Paul A McGettigan, John A Browne, Alexander CO Evans, Rita G Fonseca, Brendan J Loftus, Amanda Lohan, David E MacHugh, Barbara A Murphy, Lisa M Katz and Emmeline W Hill
Topics: Research Article
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:2900271
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (2009). 3' tag digital gene expression profiling of human brain and universal reference RNA using Illumina Genome Analyzer. BMC Genomics
  2. (1997). A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle. Nat Genet
  3. (2003). A: A novel mitochondrial carnitine-acylcarnitine translocase induced by partial hepatectomy and fasting.
  4. A: Contribution of exercise intensity and duration to training-linked myosin transitions in thoroughbreds.
  5. (2009). Abnormal glycosylation of dystroglycan in human genetic disease. Biochim Biophys Acta
  6. (1999). Ambient temperature and relative humidity influenced packed cell volume, total plasma protein and other variables in horses during an incremental submaximal field exercise test. Equine Vet J
  7. (2009). Analysis Of Equine Gene Expression By RNA Sequencing.
  8. (2009). Analysis Of Equine Structural Gene Annotation By
  9. (1998). Anflous K: Functional coupling of creatine kinases in muscles: species and tissue specificity. Mol Cell Biochem
  10. (1998). Antiphase circadian expression between BMAL1 and period homologue mRNA in the suprachiasmatic nucleus and peripheral tissues of rats.
  11. (1969). Astrand I: Physical training in sedentary middle-aged and older men. II. Oxygen uptake, heart rate, and blood lactate concentration at submaximal and maximal exercise.
  12. BABELOMICS: a systems biology perspective in the functional annotation of genome-scale experiments.
  13. (2005). Bamman MM: Impact of resistance loading on myostatin expression and cell cycle regulation in young and older men and women.
  14. (2007). BJ: Ca2+/calmodulinbased signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression. Appl Physiol Nutr Metab
  15. (2006). BP: Evidence of an oscillating peripheral clock in an equine fibroblast cell line and adipose tissue but not in peripheral blood. Journal of comparative physiology
  16. (2008). C: IGFBP-5 regulates muscle cell differentiation by binding to IGF-II and switching on the IGF-II auto-regulation loop.
  17. (1999). CA: Inventory of high-abundance mRNAs in skeletal muscle of normal men. Genome Res
  18. (1990). Comparison of two regimens of concurrent strength and endurance training. Med Sci Sports Exerc
  19. (2006). Concurrent strength and endurance training: from molecules to man. Med Sci Sports Exerc
  20. (1995). Controlling the false discovery rate - a practical and powerful approach to multiple testing.
  21. (1989). CR: Oxygen transport during exercise in large mammals. I. Adaptive variation in oxygen demand.
  22. (1989). CR: Total muscle mitochondrial volume in relation to aerobic capacity of horses and steers. Pflugers Arch
  23. (2003). Current concepts of oxygen transport during exercise. Equine and Comparative Exercise Physiology
  24. (2004). DA: Mutants of plasminogen activator inhibitor-1 designed to inhibit neutrophil elastase and cathepsin G are more effective in vivo than their endogenous inhibitors.
  25. (2003). Database for Annotation, Visualization, and Integrated Discovery. Genome Biol
  26. (2002). Davenne D: Effects of regular training at the same time of day on diurnal fluctuations in muscular performance.
  27. (1991). Dement WC: Regularly scheduled voluntary exercise synchronizes the mouse circadian clock.
  28. Digital gene expression by tag sequencing on the illumina genome analyzer.
  29. (1993). DM: Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women.
  30. (2007). Doping with growth hormone/IGF-1, anabolic steroids or erythropoietin: is there a cancer risk? Pharmacol Res
  31. (2005). Dystroglycan: important player in skeletal muscle and beyond. Neuromuscul Disord
  32. E: Differential expression of equine muscle biopsy proteins during normal training and intensified training in young standardbred horses using proteomics technology.
  33. (2007). E: Diurnal variation in temperature, mental and physical performance, and tasks specifically related to football (soccer). Chronobiol Int
  34. (2008). E: The effect of physical exercise on the daily rhythm of platelet aggregation and body temperature in horses.
  35. (2007). EA: A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs. PLoS Genet
  36. (2000). Early and long-term changes of equine skeletal muscle in response to endurance training and detraining. Pflugers Arch
  37. (2002). Effect of growth and training on muscle adaptation in Thoroughbred horses.
  38. (2004). Effect of high intensity training on anaerobic capacity of middle gluteal muscle in Thoroughbred horses. Res Vet Sci
  39. (2006). Endurance training modulates the muscular transcriptome response to acute exercise. Pflugers Arch
  40. (2009). Ensembl
  41. (2001). Entrainment of the circadian clock in the liver by feeding. Science
  42. (1992). Eppenberger HM: Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis.
  43. (1985). ER: Endurance training in humans: aerobic capacity and structure of skeletal muscle.
  44. (2001). Esser KA: Intracellular signaling specificity in skeletal muscle in response to different modes of exercise.
  45. (2009). EW: A genome scan for positive selection in thoroughbred horses. PLoS One
  46. (2010). EW: Sequence variants in equine CKM (creatine kinase, muscle) and COX4I2 (cytochrome c oxidase, subunit 4, isoform 2) genes are associated with elite racing performance in Thoroughbred horses.
  47. (2009). EW: Transcriptional adaptations following exercise in McGivney et al.
  48. (2007). Exercise as a synchroniser of human circadian rhythms: an update and discussion of the methodological problems.
  49. (1968). Exercise electrocardiography in the horse by radiotelemetry.
  50. (2007). Falgairette G: Morning-toevening differences in oxygen uptake kinetics in short-duration cycling exercise. Chronobiol Int
  51. (1974). Fibre composition, enzyme activity and concentrations of metabolites and electrolytes in muscles of standardbred horses. Acta Vet Scand
  52. (2009). FM: Structural and functional-annotation of an equine whole genome oligoarray.
  53. (1999). Free radicals and oxidative stress in exercise--immunological aspects. Exerc Immunol Rev
  54. (2007). From genes to functional classes in the study of biological systems.
  55. (1976). GA: Cardiac monitoring during exercise tests in the horse. 2. Heart rate responses to exercise. Australian veterinary journal
  56. Gene expression profiling from leukocytes of horses affected by osteochondrosis.
  57. (1993). Geyssant A: Effects of training in normoxia and normobaric hypoxia on human muscle ultrastructure. Pflugers Arch
  58. (1993). GL: Exercise induces a transient increase in transcription of the GLUT-4 gene in skeletal muscle.
  59. (2005). GR: Time course of molecular responses of human skeletal muscle to acute bouts of resistance exercise.
  60. (2006). Hawley JA: Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans.
  61. (2007). Hawley JA: Effect of high-frequency resistance exercise on adaptive responses in skeletal muscle. Med Sci Sports Exerc
  62. (1968). Heart rate response to submaximal exercise in the Standardbred horse.
  63. (1970). Heart rates and blood lactate concentrations of standardbred horses during training and racing.
  64. (2003). Hood DA: Plasticity of skeletal muscle mitochondria in response to contractile activity. Exp Physiol
  65. (2009). Human core temperature responses during exercise and subsequent recovery: an important interaction between diurnal variation and measurement site. Chronobiol Int
  66. Human growth hormone doping in sport.
  67. (2009). I: Compatibility of concurrent aerobic and resistance training on maximal aerobic capacity in sedentary males.
  68. (1985). Influences of endurance training on the ultrastructural composition of the different muscle fiber types in humans. Pflugers Arch
  69. (2002). Insulin-like growth factor-binding protein-5 (IGFBP-5) stimulates growth and IGF-I secretion in human intestinal smooth muscle by Ras-dependent activation
  70. (1980). Interference of strength development by simultaneously training for strength and endurance.
  71. (2009). JA: Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle.
  72. (2009). JA: Global gene expression in skeletal muscle from well-trained strength and endurance athletes. Med Sci Sports Exerc
  73. JL: Heart size estimated by echocardiography correlates with maximal oxygen uptake.
  74. (1977). JM: Physiological consequences of the biochemical adaptations to endurance exercise.
  75. (2002). JR: Moderate to vigorous physical activity and risk of upper-respiratory tract infection. Med Sci Sports Exerc
  76. (1995). Kinzler KW: Serial analysis of gene expression. Science
  77. (2007). KN: ACTN3: A genetic influence on muscle function and athletic performance. Exerc Sport Sci Rev
  78. (1993). Kuznetsov AV: Influence of the mitochondrial outer membrane and the binding of creatine kinase to the mitochondrial inner membrane on the compartmentation of adenine nucleotides in the intermembrane space of rat heart mitochondria. Biochim Biophys Acta
  79. (2002). LE: High intensity exercise conditioning increases accumulated oxygen deficit of horses. Equine Vet J
  80. (2009). MJ: Transcript length bias in RNA-seq data confounds systems biology. Biol Direct
  81. (2000). Mucosal immune responses and risk of respiratory illness in elite athletes. Exerc Immunol Rev
  82. (1993). Muscle characteristics in standardbreds of different ages and sexes. Equine Vet J
  83. (2007). Muscle transcriptome adaptations with mild eccentric ergometer exercise. Pflugers Arch
  84. (1987). Muscle, bone and fat proportions and muscle distribution of Thoroughbreds and other horses.
  85. (2003). Myostatin gene expression is reduced in humans with heavy-resistance strength training: a brief communication. Exp Biol Med (Maywood)
  86. (2004). Myostatin mutation associated with gross muscle hypertrophy in a child.
  87. Oral L-carnitine combined with training promotes changes in skeletal muscle.
  88. (1989). Order U: Plasma elastase-alpha 1-antitrypsin, neopterin, tumor necrosis factor, and soluble interleukin-2 receptor after prolonged exercise.
  89. (2003). PD: Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle.
  90. (2007). PV: Bimodal recovery pattern in human skeletal muscle induced by exhaustive stretch-shortening cycle exercise. Med Sci Sports Exerc
  91. (1995). R: mRNAs of enzymes involved in energy metabolism and mtDNA are increased in endurance-trained athletes.
  92. (2003). RA: Identifying biological themes within lists of genes with EASE. Genome Biol
  93. (2002). RC: Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev
  94. (1994). Regulation of neutrophil function during exercise. Sports Med
  95. RJ: Effects of prolonged training, overtraining and detraining on skeletal muscle metabolites and enzymes.
  96. (2005). Role of Ca2+/calmodulin-dependent kinases in skeletal muscle plasticity.
  97. (1999). RR: Resistance training reduces the acute exercise-induced increase in muscle protein turnover.
  98. (1992). SG: Skeletal muscle characteristics in young trained and untrained standardbred trotters. Equine Vet J
  99. (1998). Shek PN: Immune responses to inflammation and trauma: a physical training model.
  100. (2001). Shek PN: The cytokine response to physical activity and training. Sports Med
  101. (1999). Sides RH: Differences in the ventilatory responses of horses and ponies to exercise of varying intensities. Equine Vet J Suppl
  102. (1997). SJ: Double muscling in cattle due to mutations in the myostatin gene. Proc Natl Acad Sci USA
  103. (2004). SJ: Myostatin mutation associated with gross muscle hypertrophy in a child.
  104. (1997). SJ: Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature
  105. (1993). Skeletal muscle histochemistry in male and female Andalusian and Arabian horses of different ages. Res Vet Sci
  106. (2006). SM: Resistance training reduces wholebody protein turnover and improves net protein retention in untrained young males. Appl Physiol Nutr Metab
  107. (2007). Smyth GK: Moderated statistical tests for assessing differences in tag abundance. Bioinformatics
  108. (1994). Strauss AW: Expression of the mitochondrial creatine kinase genes. Mol Cell Biochem
  109. (2008). Supplizi AV: Exercise induced stress in horses: selection of the most stable reference genes for quantitative RT-PCR normalization.
  110. (2009). Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc
  111. (1995). T: Genomic DNA organization of human mitochondrial very-long-chain acyl-CoA dehydrogenase and mutation analysis.
  112. (2005). Tarnopolsky MA: Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise.
  113. (2008). The UCSC Genome Browser Database:
  114. (2009). Transcriptional profiling differences for articular cartilage and repair tissue in equine joint surface lesions. BMC Med Genomics
  115. (2005). Trappe S: Time course of myogenic and metabolic gene expression in response to acute exercise in human skeletal muscle.
  116. (1995). Ultrastructural modification of human skeletal muscle tissue with 6-month moderate-intensity exercise training.
  117. (1995). Vailas AC: Compatibility of adaptive responses with combining strength and endurance training. Med Sci Sports Exerc
  118. (1998). Vet Clin North Am, Equine Pract
  119. (2005). Wackerhage H: Selective activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation.
  120. (2008). WB: Concurrent training enhances athletes' strength, muscle endurance, and other measures.
  121. (2002). Weaver DR: Coordination of circadian timing in mammals. Nature
  122. (1999). Weijs WA: Postnatal muscle fibre composition of the gluteus medius muscle of Dutch Warmblood foals; maturation and the influence of exercise.
  123. (1999). Wolfe RR: Postexercise net protein synthesis in human muscle from orally administered amino acids.