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Systemic Toll-Like Receptor Stimulation Suppresses Experimental Allergic Asthma and Autoimmune Diabetes in NOD Mice

By Aude Aumeunier, Françoise Grela, Abdulraouf Ramadan, Linh Pham Van, Emilie Bardel, Alejandro Gomez Alcala, Pascale Jeannin, Shizuo Akira, Jean-François Bach and Nathalie Thieblemont
Topics: Research Article
Publisher: Public Library of Science
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Provided by: PubMed Central

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  3. (2004). Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice.
  4. (2009). Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein.
  5. (2002). B cells regulate autoimmunity by provision of IL-10.
  6. (2000). B7/ CD28 Costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.
  7. (1980). Breeding of a non-obese, diabetic strain of mice.
  8. (1997). CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4.
  9. (2002). Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors.
  10. (2007). Chronic asthma-induced airway remodeling is prevented by toll-like receptor-7/ 8 ligand S28463.
  11. (2005). Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors.
  12. (2004). Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma.
  13. (1996). development of autoimmune diabetes.
  14. (2003). Effect of probiotic Lactobacillus strains in children with atopic dermatitis.
  15. (2002). Effects of insulin in relatives of patients with type 1 diabetes mellitus Diabetes Prevention Trial-Type 1 Diabetes Study Group.
  16. (2004). Exacerbated Th2-mediated airway inflammation and hyperresponsiveness in autoimmune diabetes-prone NOD mice: a critical role for CD1d-dependent NKT cells.
  17. (1989). Hay fever, hygiene, and household size.
  18. (2009). House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells.
  19. (2010). IL-10 mediates resistance to adoptive transfer experimental autoimmune encephalomyelitis in MyD88(2/2) mice.
  20. (2007). Immunological determinants of ventilatory changes induced in mice by dermal sensitization and respiratory challenge with toluene diisocyanate.
  21. (2007). Immunomodulatory effects of viral TLR ligands on experimental asthma depend on the additive effects of IL-12 and IL-10.
  22. (2003). Inhibition of T helper 2-type responses, IgE production and eosinophilia by synthetic lipopeptides.
  23. (2008). Innate immunity and intestinal microbiota in the development of Type 1 diabetes.
  24. (1994). Insulin-dependent diabetes mellitus as an autoimmune disease.
  25. (2007). Lipopolysaccharide inhalation exacerbates allergic airway inflammation by activating mast cells and promoting Th2 responses.
  26. (2002). Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen.
  27. (2001). Lipopolysaccharideactivated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice.
  28. (2009). Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78.
  29. (2009). Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases.
  30. (2009). Modulation of regulatory T cells in health and disease: role of toll-like receptors.
  31. (2006). MyD88 signaling controls autoimmune myocarditis induction.
  32. (2008). Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial.
  33. (2006). On regulation of phagosome maturation and antigen presentation.
  34. (2009). Pathogen recognition in the innate immune response.
  35. (2002). Pathophysiology of intestinal food allergy.
  36. (1990). Prevention of type I diabetes in NOD mice by adjuvant immunotherapy.
  37. (2003). Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebocontrolled trial.
  38. (2001). Probiotics in primary prevention of atopic disease: a randomised placebocontrolled trial.
  39. (2008). Regulatory B cells as inhibitors of immune responses and inflammation.
  40. (2003). Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide.
  41. (2004). Requirement for CD28 in the effector phase of allergic airway inflammation.
  42. (2005). RNAassociated autoantigens activate B cells by combined B cell antigen receptor/ Toll-like receptor 7 engagement.
  43. (2004). Salmonella typhimurium infection halts development of type 1 diabetes in NOD mice.
  44. (1992). Suppression of development of diabetes in NOD mice by lactate dehydrogenase virus infection.
  45. (2010). SuSB,SilverPB,GrajewskiRS,AgarwalRK,TangJ,etal.(2005) Essentialroleof the MyD88 pathway, but nonessential roles of TLRs 2, 4, and 9, in the adjuvant effect promoting Th1-mediated autoimmunity.
  46. (2007). TH2 and TH1 lung inflammation induced by airway allergen sensitization with low and high doses of double-stranded RNA.
  47. (2010). The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update.
  48. (2002). The effect of infections on susceptibility to autoimmune and allergic diseases.
  49. (2007). The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
  50. (2005). TLR2 agonist ameliorates established allergic airway inflammation by promoting Th1 response and not via regulatory T cells.
  51. (2007). TLR4 polymorphisms mediate impaired responses to respiratory syncytial virus and lipopolysaccharide.
  52. (2006). TLR4 signaling attenuates ongoing allergic inflammation.
  53. (2006). TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway.
  54. (2003). Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells.
  55. (2006). Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells.
  56. (2005). Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease.
  57. (2001). Toll-like receptors control activation of adaptive immune responses.
  58. (2006). Transforming growth factor-beta and natural killer T-cells are involved in the protective effect of a bacterial extract on type 1 diabetes.
  59. (2000). Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in nonobese diabetic mice: modulation of spontaneous 60-kDa heat shock protein autoimmunity.