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Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background

By Harry A Noyes, Morris Agaba, Susan Anderson, Alan L Archibald, Andy Brass, John Gibson, Laurence Hall, Helen Hulme, Sung Jong Oh and Stephen Kemp
Topics: Research Article
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:2896378
Provided by: PubMed Central

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  1. (2005). A tractable probabilistic model for Affymetrix probe-level analysis across multiple chips. Bioinf
  2. (2007). A: A systematic strategy for large-scale analysis of genotype phenotype correlations: identification of candidate genes involved in African trypanosomiasis. Nucleic Acids Res
  3. (2007). AffyProbeMiner: a web resource for computing or retrieving accurately redefined Affymetrix probe sets. Bioinformatics
  4. (2009). Agaba M: Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection. Infect Immun
  5. (2007). Cox DR: A sequence-based variation map of 8.27 million SNPs in inbred mouse strains.
  6. (2005). CS: Genetical genomics in humans and model organisms. Trends Genet
  7. (2007). D: TNF-alpha interferes with lipid homeostasis and activates acute and proatherogenic processes. Physiol Genomics
  8. (2003). Different genetic control of cutaneous and visceral disease after Leishmania major infection in mice. Infect Immun
  9. (2008). DJ: Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids. Nat Genet
  10. (2007). DNA variation and brain region-specific expression profiles exhibit different relationships between inbred mouse strains: implications for eQTL mapping studies. Genome Biol
  11. (2009). Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been. Genes Dev
  12. (2003). High cholesterol may protect against infections and atherosclerosis. QJM
  13. (2008). JH: Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. Proc Natl Acad Sci USA
  14. (2010). JP: Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice. Parasitology
  15. (2003). Kruglyak L: Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors.
  16. (2000). Mangelsdorf DJ: Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science
  17. (2006). Mapping cis-acting regulatory variation in recombinant congenic strains. Physiol Genomics
  18. (2009). Mechanisms controlling anaemia in Trypanosoma congolense infected mice. PLoS ONE
  19. (2005). PHYLIP (Phylogeny Inference Package) version 3.6.
  20. (2006). Probe-level measurement error improves accuracy in detecting differential gene expression. Bioinf
  21. (2008). RC: Genetical genomics: spotlight on QTL hotspots. PLoS Genet
  22. (2007). Sequence polymorphisms cause many false cis eQTLs. PLoS One
  23. (2001). Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes. Prog Lipid Res
  24. (2003). Stromberg AJ: Statistical implications of pooling RNA samples for microarray experiments.
  25. (2000). Teale AJ: Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines. Mamm Genome
  26. (1997). Teale AJ: Localization of genes controlling resistance to trypanosomiasis in mice. Nat Genet
  27. (2004). The Collaborative Cross, a community resource for the genetic analysis of complex traits.
  28. (2007). The influence of genetic variation on gene expression. Genome Research
  29. (2005). The quantitative genetics of transcription. Trends Genet
  30. (2005). Thomas WK: The transcriptional consequences of mutation and natural selection in Caenorhabditis elegans. Nat Genet
  31. (2004). Vadasz C: Mouse striatal transcriptome analysis: effects of oral selfadministration of alcohol. Alcohol