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Inward Rotating Spiral Waves in Glycolysis

By Ronny Straube, Satenik Vermeer, Ernesto M. Nicola and Thomas Mair

Abstract

We report on the first observation of inward rotating spiral waves (antispirals) in a biochemical reaction-diffusion system. Experiments are performed with extracts from yeast cells in an open spatial reactor. By increasing the protein concentration of the extract we observe a transition from outward to inward propagating waves of glycolytic activity. Numerical simulations with an allosteric model for the phosphofructokinase can reproduce these inward propagating waves over a wide range of parameters if the octameric structure of yeast phosphofructokinase is taken into account

Topics: Biophysical Letter
Publisher: The Biophysical Society
OAI identifier: oai:pubmedcentral.nih.gov:2895376
Provided by: PubMed Central
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