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Self-Assembled Polymeric Micellar Nanoparticles as Nanocarriers for Poorly Soluble Anticancer Drug Ethaselen

By Xinru Li, Zhuoli Yang, Kewei Yang, Yanxia Zhou, Xingwei Chen, Yanhui Zhang, Fei Wang, Yan Liu and Lijun Ren

Abstract

A series of monomethoxy poly(ethylene glycol)-poly(lactide) (mPEG-PLA) diblock copolymers were synthesized, and mPEG-PLA micelle was fabricated and used as a nanocarrier for solubilization and delivery of a promising anticancer drug ethaselen. Ethaselen was efficiently encapsulated into the micelles by the dialysis method, and the solubility of ethaselen in water was remarkably increased up to 82 μg/mL before freeze-drying. The mean diameter of ethaselen-loaded micelles ranged from 51 to 98 nm with a narrow size distribution and depended on the length of PLA block. In vitro hemolysis study indicated that mPEG-PLA copolymers and ethaselen-loaded polymeric micelles had no hemolytic effect on the erythrocyte. The enhanced antitumor efficacy and reduced toxic effect of ethaselen-loaded polymeric micelle when compared with ethaselen-HP-β-CD inclusion were observed at the same dose in H22human liver cancer cell bearing mouse models. These suggested that mPEG-PLA polymeric micelle nanoparticles had great potential as nanocarriers for effective solubilization of poorly soluble ethaselen and further reducing side effects and toxicities of the drug

Topics: Nano Express
Publisher: Springer
OAI identifier: oai:pubmedcentral.nih.gov:2893964
Provided by: PubMed Central

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Citations

  1. (1998). 1510 Nanoscale Res Lett
  2. (2009). Drug Deliv.
  3. (2000). Go ¨pferich,
  4. (2009). Part A 87A,
  5. (1998). Release 56,
  6. (2004). Release 97,