Article thumbnail

Descriptive Epidemiology of Cholangiocarcinoma and Clonorchiasis in Korea

By Hai-Rim Shin, Jin-Kyoung Oh, Min Kyung Lim, Aesun Shin, Hyun-Joo Kong, Kyu-Won Jung, Young-Joo Won, Sohee Park, Sang-Jae Park and Sung-Tae Hong

Abstract

In 2009, infection with the liver fluke Clonorchis sinensis (C. sinensis) was classified as "carcinogenic to humans" (Group 1) based on its involvement in the etiology of cholangiocarcinoma by the International Agency for Research on Cancer. However, little is known about the descriptive epidemiology of cholangiocarcinoma in Korea. We examined incidence trends of intrahepatic and extrahepatic cholangiocarcinomas, using data from the Korea National Cancer Incidence database for 1999-2005. The prevalence of C. sinensis infection was estimated from a recent population-based survey in rural endemic areas. Cholangiocarcinoma incidence rates are currently rising, even while primary liver cancer incidence rates are decreasing. Annual percent changes in cholangiocarcinoma incidence rates were 8% for males and 11% in females. Known areas of C. sinensis endemicity showed high incidence rates of cholangiocarcinoma. The positivity of C. sinensis eggs in stool samples from endemic areas was more than 25% of adults tested during 2005-2008. From a meta-analysis, the summary odds ratio for cholangiocarcinoma due to C. sinensis infection was 4.7 (95% confidence interval: 2.2-9.8). Approximately 10% of cholangiocarcinomas in Korea were caused by chronic C. sinensis infections. More specific policies, including health education and an extensive effort for early detection in endemic areas, are needed

Topics: Original Article
Publisher: The Korean Academy of Medical Sciences
OAI identifier: oai:pubmedcentral.nih.gov:2890876
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (2006). A comparison of trends in the incidence of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in the United States. Cancer Epidemiol Biomarkers Prev
  2. (2004). A nationwide survey on the prevalence of intestinal parasitic infections in the Republic of Korea,
  3. (2009). A review of human carcinogens-Part B: biological agents. Lancet Oncol
  4. (1976). An epidemiological study of primary liver carcinomas in Busan area with special reference to clonorchis.
  5. (1999). Biliary tract cancers.
  6. (2006). Cholangiocarcinoma and Clonorchis sinensis infection: a case-control study in Korea.
  7. (2002). Cholangiocarcinoma: recent progress. Part 1: epidemiology and etiology.
  8. (2008). Clin Liver Dis
  9. (2005). Clonorchiasis: a key foodborne zoonosis in China. Lancet Infect Dis
  10. (2005). Clonorchiasis: an update.
  11. (2006). Clonorchis sinensis infection and increasing risk of cholangiocarcinoma in the Republic of Korea. Am J Trop Med Hyg
  12. (2003). Factors predicting concurrent cholangiocarcinomas associated with hepatolithiasis. Hepatogastroenterology
  13. (1994). for Research on Cancer. Schistosomes, liver flukes and Helicobactor pylori. IARC monographs on the evaluation of carcinogenic risks to humans., vol. 61. Lyon France: International Agency for Research on Cancer,
  14. Hepatitis B and C virus, Clonorchis sinensis for the risk of liver cancer: a case-control study in
  15. (2008). Hepatitis B virus infection and intrahepatic cholangiocarcinoma in Korea: a case-control study.
  16. (1995). Hepatolithiasis associated with cholangiocarcinoma.
  17. (2006). Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on the incidence of intra- and extrahepatic cholangiocarcinoma in the United States.
  18. (1999). Intrahepatic cholangiocarcinoma in Taiwan. J Hepatobiliary Pancreat Surg
  19. (1974). Relationship between Clonorchis sinensis infestation and cholangiocarcinoma of the liver in Korea.
  20. (2008). risk factors, and pathogenesis of cholangiocarcinoma. HPB
  21. (2003). Taxonomy and biology of liver flukes.
  22. Trends in the incidence of primary liver and biliary tract cancers
  23. (1992). World Health Organization,
  24. World Health Organization.