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γ-Aminobutyric Acid (GABA) Is an Autocrine Excitatory Transmitter in Human Pancreatic β-Cells

By Matthias Braun, Reshma Ramracheya, Martin Bengtsson, Anne Clark, Jonathan N. Walker, Paul R. Johnson and Patrik Rorsman
Topics: Islet Studies
Publisher: American Diabetes Association
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Provided by: PubMed Central

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  3. Association between 5-hydroxytryptamine release and insulin secretion.
  4. (1988). Automated method for isolation of human pancreatic islets. Diabetes
  5. (1999). Comparison of amperometric methods for detection of exocytosis from single pancreatic betacells of different species.
  6. (2005). Comparison of cellular and medium insulin and GABA content as markers for living beta-cells.
  7. Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells.
  8. (1992). Electrophysiology of stimulus-secretion coupling in human beta-cells.
  9. (1992). Erecin ´ska M. GABA in pancreatic islets: metabolism and function.
  10. Excitatory actions of gaba during development: the nature of the nurture.
  11. (1991). GABA and pancreatic beta-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion.
  12. Gamma-aminobutyric acid up- and downregulates insulin secretion from beta cells in concert with changes in glucose concentration.
  13. Glucose induces glucagon release pulses antisynchronous with insulin and sensitive to purinoceptor inhibition.
  14. (2010). Glucose inhibition of glucagon secretion from rat alpha-cells GABA
  15. Glucose-dependent regulation of gammaaminobutyric acid (GABA A) receptor expression in mouse pancreatic islet alpha-cells.
  16. Glucose-induced electrical activity in rat pancreatic beta-cells: dependence on intracellular chloride concentration.
  17. Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels.
  18. (1994). Gramicidin perforated patch-clamp technique reveals glycine-gated outward chloride current in dissociated nucleus solitarii neurons of the rat.
  19. High concentration of gamma-aminobutyric acid in pancreatic beta cells.
  20. Identification of the GABAA receptor subtype mRNA in human pancreatic tissue.
  21. (2010). Increase in postprandial serum insulin levels in epileptic patients with valproic acid therapy.
  22. Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system.
  23. (1986). Intra-islet insulin-glucagon-somatostatin relationships. Clin Endocrinol Metab
  24. Islet beta-cell secretion determines glucagon release from neighbouring alphacells.
  25. (1989). Large-scale purification of human islets utilizing discontinuous albumin gradient on IBM 2991 cell separator. Diabetes
  26. Microfluorometric analysis of Cl- permeability and its relation to oscillatory Ca2 signalling in glucose-stimulated pancreatic beta-cells.
  27. (1997). Multiple exocytotic pathways in pancreatic beta cells.
  28. Nutrient control of insulin secretion in isolated normal human islets.
  29. (1997). Nutrient regulation of gamma-aminobutyric acid release from islet beta cells. Diabetologia
  30. (2006). Paradoxical stimulation of glucagon secretion by high glucose concentrations. Diabetes
  31. R-type Ca(2)-channel-evoked CICR regulates glucoseinduced somatostatin secretion.
  32. Regulated exocytosis of GABAcontaining synaptic-like microvesicles in pancreatic beta-cells.
  33. Secretory granule-mediated cosecretion of L-glutamate and glucagon triggers glutamatergic signal transmission in islets of Langerhans.
  34. (2009). Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells. Diabetologia
  35. (1974). The preparation of, and studies on, free cell suspensions from mouse pancreatic islets. Diabetologia
  36. The unique cytoarchitecture of human pancreatic islets has implications for islet cell function.
  37. (2004). Tonically active GABA A receptors: modulating gain and maintaining the tone. Trends Neurosci
  38. (1996). Vesicular quantal size measured by amperometry at chromaffin, mast, pheochromocytoma, and pancreatic beta-cells.
  39. (1995). Voltage-dependent Na and Ca2 currents in human pancreatic islet beta-cells: evidence for roles in the generation of action potentials and insulin secretion. Pflugers Arch
  40. Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion.