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Pd-catalyzed decarboxylative Heck vinylation of 2-nitrobenzoates in the presence of CuF2

By Lukas J Gooßen, Bettina Zimmermann and Thomas Knauber


A new protocol for the decarboxylative Heck vinylation of benzoic acids is disclosed. In the presence of a catalyst system generated in situ from Pd(OAc)2 (2 mol %), CuF2 (2 equiv), and benzoquinone (0.5 equiv) in NMP, a wide range of olefins were coupled with various 2-nitrobenzoates at 130 °C with the release of carbon dioxide to afford the corresponding vinyl arenes in good yields

Topics: Full Research Paper
Publisher: Beilstein-Institut
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Provided by: PubMed Central
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