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Peroxisomal Membrane Proteins Insert into the Endoplasmic Reticulum

By Adabella van der Zand, Ineke Braakman and Henk F. Tabak

Abstract

We demonstrate that the entry of peroxisomal membrane proteins (PMPs) into the ER is mediated by the general ER import machinery. Within the ER, PMPs attain their correct topology and subsequently travel to peroxisomes. Our results show that the ER forms an obligate requirement to maintain peroxisomes in multiplying cells

Topics: Articles
Publisher: The American Society for Cell Biology
OAI identifier: oai:pubmedcentral.nih.gov:2883949
Provided by: PubMed Central
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