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Negative Potentials Across Biological Membranes Promote Fusion by Class II and Class III Viral Proteins

By Ruben M. Markosyan and Fredric S. Cohen


Fusion of virions pseudotyped with a class II, SFV E1 or VEEV E, or a class III protein, VSV G is promoted by negative potentials and hindered by positive potentials across the target cell. Hemifusion is independent of polarity. Reversion of hemifused membranes into two distinct ones is responsible for voltage-dependence and inhibition of fusion

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Publisher: The American Society for Cell Biology
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Provided by: PubMed Central
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