Article thumbnail

Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD

By Simona E Budulac, Dirkje S Postma, Pieter S Hiemstra, Lisette IZ Kunz, Mateusz Siedlinski, Henriette A Smit, Judith M Vonk, Bea Rutgers, Wim Timens and H Marike Boezen
Topics: Research
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:2882908
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (2008). ABC multidrug transporters: structure, function and role in chemoresistance. Pharmacogenomics
  2. (1999). ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1. Br J Pharmacol
  3. (2005). CG: A functional polymorphism within the MRP1 gene locus identified through its genomic signature of positive selection. Hum Mol Genet
  4. (1994). Characterization of the ATPdependent leukotriene C4 export carrier in mastocytoma cells.
  5. (1998). Cole SP: Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione. Cancer Res
  6. (1999). Cole SP: Structural, mechanistic and clinical aspects of MRP1. Biochim Biophys Acta
  7. (2001). Cole SP: Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters. Toxicology
  8. (2007). de Vries EG, Kerstjens HA: Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice. Respir Res
  9. (2002). de Vries EG, Scheper RJ: Multidrug resistance related molecules in human and murine lung.
  10. (2006). de Vries EG, Timens W: Diminished expression of multidrug resistance-associated protein 1 (MRP1) in bronchial epithelium of COPD patients. Virchows Arch
  11. (1992). Deeley RG: Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science
  12. (2007). DS: A disintegrin and metalloprotease 33 and chronic obstructive pulmonary disease pathophysiology. Thorax
  13. (2009). DS: ABCC1 polymorphisms contribute to level and decline of lung function in two population-based cohorts. Pharmacogenet Genomics
  14. (2005). DS: ATP-binding cassette (ABC) transporters in normal and pathological lung. Respir Res
  15. (1996). EH: Repeatability of cellular and soluble markers of inflammation in induced sputum from patients with asthma. Eur Respir J
  16. (2007). Hiemstra PS: Smoking cessation and bronchial epithelial remodelling in COPD: a cross-sectional study. Respir Res
  17. (2008). HM: Lung function loss, smoking, vitamin C intake, and polymorphisms of the glutamate-cysteine ligase genes. Am J Respir Crit Care Med
  18. (1998). JF: Different pattern of MRP localization in ciliated and basal cells from human bronchial epithelium.
  19. (2006). Kerstjens HA: Increased number of Bcells in bronchial biopsies in COPD. Eur Respir J
  20. (2006). Mauad T: Relation between duration of smoking cessation and bronchial inflammation in COPD. Thorax
  21. (2006). MR: Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance. Pharmacogenet Genomics
  22. (2004). Paré PD: The nature of smallairway obstruction in chronic obstructive pulmonary disease.
  23. (1996). PJ: Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med
  24. (1997). PK: Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1. Am J Respir Crit Care Med
  25. (2005). Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease. Proc Am Thorac Soc
  26. (2003). Real-time reverse transcription-PCR expression profiling of the complete human ATP-binding cassette transporter superfamily in various tissues. Clin Chem
  27. (2004). Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J
  28. (2004). Sterk PJ: Dissociation of lung function and airway inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med
  29. (2005). Timens W: Association of current smoking with airway inflammation in chronic obstructive pulmonary disease and asymptomatic smokers. Respir Res
  30. (2007). Timmer-Bosscha H: Cigarette smoke extract affects functional activity of MRP1 in bronchial epithelial cells. J Biochem Mol Toxicol
  31. (1994). Twentyman PR: Expression of the multidrug resistance-associated protein (MRP) gene in human lung tumours and normal tissue as determined by in situ hybridisation.