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Dkk1 Stabilizes Wnt Co-Receptor LRP6: Implication for Wnt Ligand-Induced LRP6 Down-Regulation

By Yonghe Li, Wenyan Lu, Taj D. King, Chia-Chen Liu, Gautam N. Bijur and Guojun Bu
Topics: Research Article
Publisher: Public Library of Science
OAI identifier: oai:pubmedcentral.nih.gov:2882367
Provided by: PubMed Central

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Citations

  1. (2006). A
  2. A (2008) Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling.
  3. A (2010) LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse.
  4. (2006). A critical role for endocytosis in Wnt signaling.
  5. (1997). A member of the Frizzled protein family mediating axis induction by Wnt-5A.
  6. (2003). A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.
  7. (2007). Bafico A
  8. (2004). Defective downregulation of receptor tyrosine kinases in cancer.
  9. (1999). Dickkopf genes are co-ordinately expressed in mesodermal lineages.
  10. (1998). Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction.
  11. (1997). Differential functions of triplicated repeats suggest two independent roles for the receptorassociated protein as a molecular chaperone.
  12. (2008). DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradation.
  13. (2006). Endocytic trafficking of Wingless and its receptors, Arrow and DFrizzled-2, in the Drosophila wing.
  14. (1998). growth alterations and signaling pathways in NIH3T3 fibroblasts.
  15. (2001). Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.
  16. (1997). Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signaling.
  17. (2006). Internalization is required for proper Wingless signaling in Drosophila melanogaster.
  18. (2004). Kaykas A
  19. (2007). Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling.
  20. (2002). Kremen proteins are Dickkopf receptors that regulate Wnt/b-catenin signaling.
  21. (2004). LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.
  22. (2001). LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.
  23. (2005). Lipoprotein particles are required for Hedgehog and Wingless signaling.
  24. (2005). LRP5/6 in Wnt signaling and tumorigenesis.
  25. (2004). LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering beta-catenin subcellular distribution.
  26. (2005). Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding.
  27. (2003). Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity.
  28. (2010). Negative regulation of bone formation by the transmembrane Wnt antagonist
  29. (2001). Novel mechanism of Wnt signaling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow.
  30. (2003). Receptor downregulation and multivesicular-body sorting.
  31. (2001). Regulated endocytic routing modulates wingless signaling in Drosophila embryos.
  32. (2006). Regulation of bone mass by Wnt signaling.
  33. (2005). Role of the intracellular domains of LRP5 and LRP6 in activating the Wnt canonical pathway.
  34. (2008). Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density.
  35. (2006). The endocytic pathway and formation of the Wingless morphogen gradient.
  36. (2004). The Wnt signaling pathway in development and disease.
  37. (2000). Wingless gradient formation in the Drosophila wing.