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Ligand-binding site prediction of proteins based on known fragment–fragment interactions

By Kota Kasahara, Kengo Kinoshita and Toshihisa Takagi


Motivation: The identification of putative ligand-binding sites on proteins is important for the prediction of protein function. Knowledge-based approaches using structure databases have become interesting, because of the recent increase in structural information. Approaches using binding motif information are particularly effective. However, they can only be applied to well-known ligands that frequently appear in the structure databases

Topics: Original Papers
Publisher: Oxford University Press
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Provided by: PubMed Central

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