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Resistance Training Increases Muscle Mitochondrial Biogenesis in Patients with Chronic Kidney Disease

By Vaidyanatha S. Balakrishnan, Madhumathi Rao, Vandana Menon, Patricia L. Gordon, Monika Pilichowska, Francisco Castaneda and Carmen Castaneda-Sceppa


Background and objectives: Muscle wasting, a common complication in chronic kidney disease (CKD), contributes to poor outcomes. Mitochondrial biogenesis is critical for the maintenance of skeletal muscle function and structural integrity. The present study—a secondary analysis from a published randomized controlled trial—examined the effect of resistance exercise training on skeletal muscle mitochondrial (mt)DNA copy number and determined its association with skeletal muscle phenotype (muscle mass and strength)

Topics: Original Articles
Publisher: American Society of Nephrology
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Provided by: PubMed Central
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