Article thumbnail

Captopril reduces cardiac inflammatory markers in spontaneously hypertensive rats by inactivation of NF-kB

By José L Miguel-Carrasco, Sonia Zambrano, Antonio J Blanca, Alfonso Mate and Carmen M Vázquez
Topics: Research
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:2879251
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (1998). ACE inhibitor quinapril reduces the arterial expression of NF-kappaBdependent proinflammatory factors but not of collagen I in a rabbit model of atherosclerosis.
  2. (2002). Activation and suppression of reninangiotensin system in human dendritic cells. Biochem Biophys Res Commun
  3. (2005). Alican I: The effect of angiotensin-converting enzyme inhibitors on experimental colitis in rats. Regul Pept
  4. (1999). Angiotensin II activates the proinflammatory transcription factor nuclear factor-kappaB in human monocytes. Biochem Biophys Res Commun
  5. (2004). Angiotensin II differentially regulates interleukin-1-beta-inducible NO synthase (iNOS) and vascular cell adhesion molecule-1 (VCAM-1) expression: role of p38 MAPK.
  6. (1999). Angiotensin II induces vascular cell adhesion molecule-1 expression in rat vasculature: A potential link between the renin-angiotensin system and atherosclerosis. Circulation
  7. (2002). BC: Angiotensin II-mediated signal transduction pathways. Curr Hypertens Rep
  8. (2004). BJ: Temporal characteristics of cardiomyocyte hypertrophy in the spontaneously hypertensive rat. Cardiovasc Pathol
  9. (2005). Cachofeiro V: Effect of AT1 receptor antagonism on vascular and circulating inflammatory mediators in SHR: role of NF-kappaB/IkappaB system.
  10. (2008). Carretero OA: Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage. Am J Physiol Heart Circ Physiol
  11. (2000). CG: Enalapril and captopril enhance glutathione-dependent antioxidant defenses in mouse tissues.
  12. (1997). CH: Effect of angiotensin-converting enzyme inhibition on myocardial fibrosis and function in hypertrophied and failing myocardium from the spontaneously hypertensive rat. Circulation
  13. (2010). CM: Comparative effects of captopril and l-carnitine on blood pressure and antioxidant enzyme gene expression in the heart of spontaneously hypertensive rats.
  14. (2008). CM: The role of inflammatory markers in the cardioprotective effect of L-carnitine in L-NAME-induced hypertension.
  15. (2005). E: Effects of candesartan cilexetil and enalapril on inflammatory markers of atherosclerosis in hypertensive patients with non-insulindependent diabetes mellitus.
  16. (1999). Effect of captopril in L-NAMEinduced hypertension on the rat myocardium, aorta, brain and kidney. Exp Physiol
  17. (2009). Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats.
  18. (2000). Effects of captopril on interleukin-6, leukotriene B(4), and oxidative stress markers in serum and inflammatory exudate of arthritic rats: evidence of antiinflammatory activity. Toxicol Appl Pharmacol
  19. (2009). Faraci FM: Endogenous interleukin-10 inhibits angiotensin II-induced vascular dysfunction. Hypertension
  20. (2000). FC: NF-kappaB inhibition ameliorates angiotensin II-induced inflammatory damage in rats. Hypertension
  21. (2002). FM: Interleukin-10 protects nitric oxidedependent relaxation during diabetes: role of superoxide. Diabetes
  22. (2004). H: Comparative effects of AT1-antagonism and angiotensin-converting enzyme inhibition on markers of inflammation and platelet Miguel-Carrasco et al.
  23. (2002). HK: Induction of higher expression of IL-beta and TNF-alpha, lower expression of IL-10 and cyclic guanosine monophosphate by pulmonary arterial hypertension following cardiopulmonary bypass.
  24. (1999). Hypertension-induced end-organ damage: A new transgenic approach to an old problem. Hypertension
  25. (2006). Inflammation of different tissues in spontaneously hypertensive rats. Sheng Li Xue Bao
  26. (2000). JB: Molecular plasticity of vascular wall during N(G)-nitro-L-arginine methyl ester-induced hypertension: modulation of proinflammatory signals. Hypertension
  27. (2006). JM: Regulation of sodium-glucose cotransporter SGLT1 in the intestine of hypertensive rats.
  28. (2008). KN: Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy. Kidney Int
  29. (1993). KT: Angiotensin-converting enzyme and myocardial fibrosis in the rat receiving angiotensin II or aldosterone.
  30. (2010). Lack of beneficial metabolic effects of quercetin in adult spontaneously hypertensive rats.
  31. (2006). Manning RD Jr: Renal NFkappaB activation and TNF-alpha upregulation correlate with saltsensitive hypertension in Dahl salt-sensitive rats.
  32. (2007). ML: Vascular Angiotensin type 1 receptor expression is associated with vascular dysfunction, oxidative stress and inflammation in fructose-fed rats. Hypertens Res
  33. (2000). MS: Angiotensin II induces gene transcription through cell-type-dependent effects on the nuclear factor-kappaB (NF-kappaB) transcription factor. Mol Cell Biochem
  34. (2000). Nurminen ML: Role of endothelium and nitric oxide in experimental hypertension. Physiol Res
  35. (2006). Ohno S: Captopril suppresses inflammation in endotoxin-induced uveitis in rats. Exp Eye Res
  36. (2007). Ozawa K: Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats. Circ Res
  37. (2009). Pechanova O: Comparison of the effects of indapamide and captopril on the development of spontaneous hypertension.
  38. (2003). PL: Endothelial activation by angiotensin II through NFkappaB and p38 pathways: Involvement of NFkappaB-inducible kinase (NIK), free oxygen radicals, and selective inhibition by aspirin.
  39. (1997). Rapid communication. Enalapril decreases nuclear factor kappa B activation in the kidney with urethral obstruction. Kidney Int
  40. (2003). Renal sympathetic nerve responses to tempol in spontaneously hypertensive rats. Hypertension
  41. (2005). Rhaleb NE: Angiotensin-converting enzyme inhibitors: a new mechanism of action. Circulation
  42. (2007). Rhaleb NE: Role of N-acetylseryl-aspartyl-lysyl-proline in the antifibrotic and anti-inflammatory effects of the angiotensin-converting enzyme inhibitor captopril in hypertension. Hypertension
  43. (2005). Romero JC: Effects of captopril on the renin angiotensin system, oxidative stress, and endothelin in normal and hypertensive rats. Hypertension
  44. (1995). Rostami A: Effects of the angiotensin converting enzyme inhibitor captopril on experimental autoimmune encephalomyelitis. Immunopharmacol Immunotoxicol
  45. (2006). Schiffrin EL: Inflammation in hypertension. Curr Opin Nephrol Hypertens
  46. (2002). Schiffrin EL: Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: role of peroxisome proliferator-activated receptor-gamma. Circulation
  47. (2007). Schiffrin EL: Vascular inflammation in hypertension and diabetes: molecular mechanisms and therapeutic interventions. Clin Sci (Lond)
  48. (2006). Simko F: Effect of spironolactone and captopril on nitric oxide and Snitrosothiol formation in kidney of L-NAME-treated rats. Kidney Int
  49. (1997). Simko F: Protein remodelling of the heart in NO-deficient hypertension: the effect of captopril.
  50. (2000). Simko F: Regression of chronic L -NAME-treatment-induced left ventricular hypertrophy: effect of captopril.
  51. (1996). T: Chronic L-arginine administration attenuates cardiac hypertrophy in spontaneously hypertensive rats. Hypertension
  52. (2004). T: The inhibitory effect of alacepril, an angiotensin-converting enzyme inhibitor, on endothelial inflammatory response induced by oxysterol and TNF-alpha. Redox Rep
  53. (1997). Takeshita A: Chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade: effects on cardiovascular remodeling in rats induced by the long-term blockade of nitric oxide synthesis. Hypertension
  54. (2000). Takeshita A: Role of monocyte chemoattractant protein-1 in cardiovascular remodeling induced by chronic blockade of nitric oxide synthesis. Circulation
  55. (2006). TB: Regulating the regulator: NF-kappaB signaling in heart.
  56. (1999). Tedgui A: Protective role of interleukin-10 in atherosclerosis. Circ Res
  57. (2010). The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4(+)CD103(+)CD25(negative) splenic T cell numbers. Cell Immunol
  58. (1993). The electrophysiological characteristics of hypertrophied ventricular myocytes from the spontaneously hypertensive rat. J Hypertens
  59. (2006). The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: twentysomething years on. Nat Protoc
  60. (2001). Thien T: Pro-inflammatory cytokines in patients with essential hypertension.