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Dicoumarol enhances gemcitabine-induced cytotoxicity in high NQO1-expressing cholangiocarcinoma cells

By Benjaporn Buranrat, Auemduan Prawan, Upa Kukongviriyapan, Sarinya Kongpetch and Veerapol Kukongviriyapan

Abstract

AIM: To investigate whether dicoumarol, a potent inhibitor of NAD(P)H quinone oxidoreductase-1 (NQO1), potentiates gemcitabine to induce cytotoxicity in cholangiocarcinoma cells (CCA) and the role of reactive oxygen generation in sensitizing the cells

Topics: Original Article
Publisher: The WJG Press and Baishideng
OAI identifier: oai:pubmedcentral.nih.gov:2874140
Provided by: PubMed Central
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