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Characterization of H9N2 influenza A viruses isolated from chicken products imported into Japan from China

By M. MASE, M. ETO, K. IMAI, K. TSUKAMOTO and S. YAMAGUCHI

Abstract

We characterized eleven H9N2 influenza A viruses isolated from chicken products imported from China. Genetically they were classified into six distinct genotypes, including five already known genotypes and one novel genotype. This suggested that such multiple genotypes of the H9N2 virus have possibly already become widespread and endemic in China. Two isolates have amino-acid substitutions that confer resistance to amantadine in the M2 region, and this supported the evidence that this mutation might be a result of the wide application of amantadine for avian influenza treatment in China. These findings emphasize the importance of surveillance for avian influenza virus in this region, and of quarantining imported chicken products as potential sources for the introduction of influenza virus

Topics: Research Article
Publisher: Cambridge University Press
OAI identifier: oai:pubmedcentral.nih.gov:2870580
Provided by: PubMed Central
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