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Assessment of neonatal tetanus elimination in an African setting by lot quality assurance cluster sampling (LQA-CS).

By B. Cotter, V. Bremer, G. Stroh, K. Msambichaka, E. Mabuzane, M. Munyoro, F. Shirehwa, R. Biellik and M. Birmingham


Neonatal tetanus (NT) elimination, < 1 case per 1,000 live births (LB), was assessed at district level in Zimbabwe using a combined lot quality assurance-cluster sampling survey (LQA-CS). Three of the highest risk districts were selected. NT was considered eliminated if fewer than a specified number of NT deaths (proxy for NT cases) were found in the sample determined using operating characteristic curves and tables. TT2 + vaccine coverage was measured in mothers who gave birth 1-13 months before the survey and women aged 15-49 years. NT was considered as eliminated, TT2+ coverage was 78% (95% CI 71-82%) in women aged 15-49 and 83% (95% CI 76-89%) in mothers. The survey cost 30,000 US dollars excluding costs of consultants. NT incidence was below the elimination threshold (< 1/1,000 LB) in the surveyed districts and probably in all districts. LQA-CS is a practical, relatively cost effective field method which can be applied in an African setting to assess NT elimination status

Topics: Research Article
Publisher: Cambridge University Press
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Provided by: PubMed Central
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