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Deformability-based sorting of red blood cells in deterministic lateral displacement devices

By Z. Zhang, K. Punyani, Ewan Henry, S. H. Holm, J. P. Beech, J. O. Tegenfeldt, Gerhard Gompper and Dmitry A. Fedosov

Abstract

Mesoscopic simulations with two-dimensional (2D) models have been performed to elucidate the dynamics of deformable red blood cells (RBCs) in deterministic lateral displacement (DLD) devices. Several shapes of posts, including circular, diamond, square and triangular structures and RBCs with different rigidities are considered. In comparison to rigid particles, the deformable RBCs exhibit much more complex dynamics within a DLD device, which not only brings additional complications but also provides new separation mechanisms (e.g., based on cell deformability). Further simulation results reveal that the post geometry which induces more cell deformation can be applied to effectively sort RBCs based on their rigidity

Topics: Medical Laboratory and Measurements Technologies, Bumper array, Mesoscopic simulation, Microfluidics, Post shape
Publisher: Chemical and Biological Microsystems Society
Year: 2016
OAI identifier: oai:lup.lub.lu.se:340a4e77-2930-45ae-a6be-42eb598ec6ba
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