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Lactoferrin Levels in Tears are Increased by the Topical Application of Diadenosine Tetraphosphate

By Patricia Loma Lozano, Ana Isabel Guzmán Aránguez, María Jesús Pérez de Lara and Jesús Pintor

Abstract

Purpose: This study was undertaken to determine the effect of the topical application of diadenosine tetraphosphate on lactoferrin levels in rabbit tears. Methods: Diadenosine tetraphosphate was topically instilled in a single-dose, tear samples were collected by micropipette and lactoferrin was measured by Enzyme-Linked ImmunoSorbent Assay (ELISA). Results: The concentration of lactoferrin in rabbit tears was significantly increased 1 h after diadenosine tetraphosphate application, remaining elevated for 3 h more. This effect was blocked by P2 receptors antagonists. Conclusions: Topical application of diadenosine tetraphosphate stimulates the secretion of lactoferrin in rabbit tears through P2 receptor activation

Topics: Bioquímica, Anatomía ocular
Publisher: 'Informa UK Limited'
Year: 2016
DOI identifier: 10.3109/02713683.2015.1113431
OAI identifier: oai:www.ucm.es:41803
Provided by: EPrints Complutense
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