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Lactoferrin Levels in Tears are Increased by the Topical Application of Diadenosine Tetraphosphate

By Patricia Loma Lozano, Ana Isabel Guzmán Aránguez, María Jesús Pérez de Lara and Jesús Pintor


Purpose: This study was undertaken to determine the effect of the topical application of diadenosine tetraphosphate on lactoferrin levels in rabbit tears. Methods: Diadenosine tetraphosphate was topically instilled in a single-dose, tear samples were collected by micropipette and lactoferrin was measured by Enzyme-Linked ImmunoSorbent Assay (ELISA). Results: The concentration of lactoferrin in rabbit tears was significantly increased 1 h after diadenosine tetraphosphate application, remaining elevated for 3 h more. This effect was blocked by P2 receptors antagonists. Conclusions: Topical application of diadenosine tetraphosphate stimulates the secretion of lactoferrin in rabbit tears through P2 receptor activation

Topics: Bioquímica, Anatomía ocular
Publisher: 'Informa UK Limited'
Year: 2016
DOI identifier: 10.3109/02713683.2015.1113431
OAI identifier:
Provided by: EPrints Complutense
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