Beta-cell deﬁcit and increased -cell apoptosis in humans with type 2 diabetes.
Beta-cell-speciﬁc deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass.
Buteau J, Roduit R, Susini S, Prentki
C. Antiapoptotic signaling generated by caspaseinduced cleavage
Calderari S, Gangnerau MN, Thibault M, Meile MJ, Kassis N, Alvarez C,
(2003). cAMP promotes pancreatic beta-cells survival via CREB-mediated induction of IRS2. Genes Dev
cAMP-dependent protein kinase and Ca inﬂux through L-type voltage-gated calcium channels mediate rafindependent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic -cells.
cAMP-GEFII is a direct target of cAMP in regulated exocytosis.