Article thumbnail
Location of Repository

Glucagon-Like Peptide-1 Protects β-Cells Against Apoptosis by Increasing the Activity of an Igf-2/Igf-1 Receptor Autocrine Loop

By Marion Cornu, Jiang-Yan Yang, Evrim Jaccard, Carine Poussin, Christian Widmann and Bernard Thorens
Topics: Original Article
Publisher: American Diabetes Association
OAI identifier: oai:pubmedcentral.nih.gov:2712796
Provided by: PubMed Central

Suggested articles

Citations

  1. (2001). A choice of death: the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia
  2. AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR,
  3. Beta-cell deficit and increased -cell apoptosis in humans with type 2 diabetes.
  4. Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass.
  5. Buteau J, Roduit R, Susini S, Prentki
  6. C. Antiapoptotic signaling generated by caspaseinduced cleavage
  7. Calderari S, Gangnerau MN, Thibault M, Meile MJ, Kassis N, Alvarez C,
  8. (2003). cAMP promotes pancreatic beta-cells survival via CREB-mediated induction of IRS2. Genes Dev
  9. cAMP-dependent protein kinase and Ca influx through L-type voltage-gated calcium channels mediate rafindependent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic -cells.
  10. cAMP-GEFII is a direct target of cAMP in regulated exocytosis.
  11. Crutchlow
  12. de Fourmestraux V, Neubauer H, Poussin C, Farmer P, Falquet L, Burcelin R, Delorenzi
  13. Debril
  14. Defective insulin secretion in pancreatic cells lacking type 1 IGF receptor.
  15. Devedjian JC,
  16. Differential sensitivity of phosphatidylinositol 3-kinase p110gamma to isoforms of G protein betagamma dimers.
  17. (1992). Expression cloning of the pancreatic beta cell receptor for the
  18. FoxO1 mediates glucagon-like peptide-1 effects on pancreatic -cell mass. Diabetes 2006; 55:1190–1196
  19. Frasca F, Pandini G, Scalia P, Sciacca L, Mineo
  20. Gao
  21. (1993). Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain. Endocrinology
  22. Glucagon-like peptide 1 induces pancreatic -cell proliferation via transactivation of the epidermal growth factor receptor.
  23. Hill DJ, Strutt B,
  24. Hoog A, Hu W, Abdel-Halim SM, Falkmer S, Qing
  25. Hoog A, Kjellman
  26. I-mediated inhibition of pancreatic beta-cell death. Endocrinology 2002;143:3802–3812
  27. Islet beta cell failure in type 2 diabetes.
  28. KM, Villa-Komaroff L, Weir GC, Bonner-Weir S. Enhanced insulin-like growth factor I gene expression in regenerating rat pancreas. Proc Natl
  29. of insulin-like growth factor II mRNA-binding proteins represses translation in late development. Mol Cell Biol 1999;19: 1262–1270 M. CORNU AND ASSOCIATES DIABETES, VOL. 58, AUGUST 2009 1825
  30. Oscillations of cyclic AMP in hormone-stimulated insulin-secreting beta-cells.
  31. Petrik J, Reusens B, Arany E, Remacle C, Coelho C, Hoet JJ, Hill DJ. A low protein diet alters
  32. Portela-Gomes
  33. (1985). Regulation of adenosine 3,5-monophosphate levels in the pancreatic B cell. Endocrinology
  34. (1987). Reproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase injection. Transplantation
  35. (2005). Rooman I. Regulation of pancreatic beta-cell mass. Physiol Rev
  36. Serradas P, Goya L, Lacorne
  37. TC,
  38. The biology of incretin hormones.
  39. to mediate pancreatic beta cell growth and function.
  40. Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.
  41. Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes.
  42. Vilsboll T, Krarup T, Sonne J, Madsbad S, Volund A,
  43. Wang Q, Li

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.